PMID- 21839727
OWN - NLM
STAT- MEDLINE
DCOM- 20111121
LR  - 20110905
IS  - 1090-2104 (Electronic)
IS  - 0006-291X (Linking)
VI  - 412
IP  - 3
DP  - 2011 Sep 2
TI  - A novel inhibitor of apoptosis protein (IAP)-interacting protein, Vestigial-like 
      (Vgl)-4, counteracts apoptosis-inhibitory function of IAPs by nuclear 
      sequestration.
PG  - 454-9
LID - 10.1016/j.bbrc.2011.07.117 [doi]
AB  - The inhibitors of apoptosis proteins (IAP), which include cIAP1, cIAP2 and XIAP, 
      suppress apoptosis through the inhibition of caspases, and the activity of IAPs 
      is regulated by a variety of IAP-binding proteins. Herein, we report the 
      identification of a Vestigial-like 4 (Vgl-4), which functions as a transcription 
      cofactor in cardiac myocytes, as a new IAP binding protein. Vgl-4 is expressed 
      predominantly in the nucleus and its overexpression triggers a relocalization of 
      IAPs from the cytoplasm to the nucleus. cIAP1/2-interacting protein TRAF2 (TNF 
      receptor-associated factor 2) prevented the Vgl-4-driven nuclear localization of 
      cIAP2. Accordingly, the forced relocation of IAPs to the nucleus by Vgl-4 
      significantly reduced their ability to prevent Bax- and TNFalpha-induced apoptosis, 
      which can be recovered by co-expression with TRAF2. Our results suggest that 
      Vgl-4 may play a role in the apoptotic pathways by regulating translocation of 
      IAPs between different cell compartments.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Jin, Hyung-Seung
AU  - Jin HS
AD  - Department of Systems Biology, College of Life Science and Biotechnology, Yonsei 
      University, Yonsei-ro 50, Seodaemoon-gu, Seoul 120-749, Republic of Korea.
FAU - Park, Hyung-Sun
AU  - Park HS
FAU - Shin, Jun-Ha
AU  - Shin JH
FAU - Kim, Dong-Hwan
AU  - Kim DH
FAU - Jun, Sung-Hun
AU  - Jun SH
FAU - Lee, Chang-Jun
AU  - Lee CJ
FAU - Lee, Tae H
AU  - Lee TH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110804
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Inhibitor of Apoptosis Proteins)
RN  - 0 (TNF Receptor-Associated Factor 2)
RN  - 0 (Transcription Factors)
RN  - 0 (VGLL4 protein, human)
RN  - 0 (X-Linked Inhibitor of Apoptosis Protein)
SB  - IM
MH  - Active Transport, Cell Nucleus
MH  - *Apoptosis
MH  - Cell Nucleus/*metabolism
MH  - HEK293 Cells
MH  - HeLa Cells
MH  - Humans
MH  - Inhibitor of Apoptosis Proteins/*metabolism
MH  - TNF Receptor-Associated Factor 2/metabolism
MH  - Transcription Factors/*metabolism
MH  - X-Linked Inhibitor of Apoptosis Protein
EDAT- 2011/08/16 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/08/16 06:00
PHST- 2011/07/22 00:00 [received]
PHST- 2011/07/27 00:00 [accepted]
PHST- 2011/08/16 06:00 [entrez]
PHST- 2011/08/16 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - S0006-291X(11)01361-1 [pii]
AID - 10.1016/j.bbrc.2011.07.117 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2011 Sep 2;412(3):454-9. doi: 
      10.1016/j.bbrc.2011.07.117. Epub 2011 Aug 4.