PMID- 21840231
OWN - NLM
STAT- MEDLINE
DCOM- 20141112
LR  - 20151119
IS  - 1532-8198 (Electronic)
IS  - 1092-9134 (Linking)
VI  - 16
IP  - 6
DP  - 2012 Dec
TI  - Colonic in situ mantle cell lymphoma.
PG  - 508-14
LID - S1092-9134(11)00080-3 [pii]
LID - 10.1016/j.anndiagpath.2011.05.001 [doi]
AB  - This report describes the first case, to our knowledge, of in situ mantle cell 
      lymphoma (MCL) in the gastrointestinal tract identified retrospectively by 
      immunostains and fluorescence in situ hybridization (FISH) analysis after 
      progression to disseminated disease with pleomorphic morphology several years 
      later. A 45-year-old man with blood per rectum underwent colonoscopy and had 
      random biopsies interpreted as benign colonic mucosa. Two years later, he 
      presented with ileocolic intussusception related to enlarged lymph nodes. 
      Biopsies on the second presentation demonstrated widespread MCL. Reevaluation of 
      the original colonic biopsies showed cyclin D1-positive cells within small 
      lymphoid aggregates, confirmed by FISH for t(11;14). Postchemotherapy, lymphoid 
      aggregates in colonic biopsies showed scattered cyclin D1- and FISH 
      t(11;14)-positive cells, similar to the original in situ lymphoma. We discuss 
      this case in the context of the current understanding of the evolution of MCL and 
      the difficulties associated with detecting primary GI lymphoma.
CI  - Published by Elsevier Inc.
FAU - Neto, Antonio G
AU  - Neto AG
AD  - Department of Pathology and Laboratory Medicine, VA Connecticut Healthcare 
      System, West Haven, CT 06516, USA.
FAU - Oroszi, Gabor
AU  - Oroszi G
FAU - Protiva, Petr
AU  - Protiva P
FAU - Rose, Michal
AU  - Rose M
FAU - Shafi, Nelofar
AU  - Shafi N
FAU - Torres, Richard
AU  - Torres R
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20110812
PL  - United States
TA  - Ann Diagn Pathol
JT  - Annals of diagnostic pathology
JID - 9800503
RN  - 0 (Biomarkers, Tumor)
RN  - 136601-57-5 (Cyclin D1)
SB  - IM
MH  - Biomarkers, Tumor/*metabolism
MH  - Biopsy
MH  - Carcinoma in Situ/drug therapy/genetics/metabolism/*pathology
MH  - Chromosomes, Human, Pair 11
MH  - Chromosomes, Human, Pair 14
MH  - Colonic Neoplasms/drug therapy/genetics/metabolism/*pathology
MH  - Colonoscopy
MH  - Cyclin D1/metabolism
MH  - Disease Progression
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Intestinal Mucosa/pathology
MH  - Lymph Nodes/pathology
MH  - Lymphoma, Mantle-Cell/drug therapy/genetics/metabolism/*pathology
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Translocation, Genetic
EDAT- 2011/08/16 06:00
MHDA- 2014/11/13 06:00
CRDT- 2011/08/16 06:00
PHST- 2011/02/23 00:00 [received]
PHST- 2011/04/18 00:00 [revised]
PHST- 2011/05/09 00:00 [accepted]
PHST- 2011/08/16 06:00 [entrez]
PHST- 2011/08/16 06:00 [pubmed]
PHST- 2014/11/13 06:00 [medline]
AID - S1092-9134(11)00080-3 [pii]
AID - 10.1016/j.anndiagpath.2011.05.001 [doi]
PST - ppublish
SO  - Ann Diagn Pathol. 2012 Dec;16(6):508-14. doi: 10.1016/j.anndiagpath.2011.05.001. 
      Epub 2011 Aug 12.