PMID- 21840242
OWN - NLM
STAT- MEDLINE
DCOM- 20120207
LR  - 20220321
IS  - 1873-5126 (Electronic)
IS  - 1353-8020 (Linking)
VI  - 17
IP  - 9
DP  - 2011 Nov
TI  - Differentiating Parkinson's disease from multiple system atrophy by [123I] 
      meta-iodobenzylguanidine myocardial scintigraphy and olfactory test.
PG  - 698-700
LID - 10.1016/j.parkreldis.2011.07.011 [doi]
AB  - We aimed to study whether either [(123)l] myocardial meta-iodobenzylguanidine 
      (MIBG) myocardial scintigraphy or the odor stick identification test for Japanese 
      (OSIT-J) is effective in differentiating Parkinson's disease (PD) from multiple 
      system atrophy (MSA). We compared the MIBG accumulation and olfactory score 
      between 42 PD and 42 MSA (19 MSA-P and 23 MSA-C) patients in the early stages. 
      [(123)l] MIBG myocardial scintigraphy showed higher sensitivity and the olfactory 
      test higher specificity in differentiating PD from MSA. There were significant 
      differences between PD and MSA-C (p = 0.0019) instead of MSA-P (p > 0.05) in the 
      MIBG accumulation, while there were significant differences between PD and MSA-P 
      (p = 0.0003) or MSA-C (p = 0.0003) in the OSIT-J score. Our data suggest that the 
      olfactory test can be useful as a clinical tool with its higher specificity in 
      differentiating PD from MSA in the early stages and, moreover, support the 
      discrimination of PD from MSA-P.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Kikuchi, Akio
AU  - Kikuchi A
AD  - Department of Neurology, Tohoku University Graduate School of Medicine, 1-1 
      Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan. akikuchi@med.tohoku.ac.jp
FAU - Baba, Toru
AU  - Baba T
FAU - Hasegawa, Takafumi
AU  - Hasegawa T
FAU - Sugeno, Naoto
AU  - Sugeno N
FAU - Konno, Masatoshi
AU  - Konno M
FAU - Takeda, Atsushi
AU  - Takeda A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110812
PL  - England
TA  - Parkinsonism Relat Disord
JT  - Parkinsonism & related disorders
JID - 9513583
RN  - 0 (Iodine Radioisotopes)
RN  - 0 (Radiopharmaceuticals)
RN  - 35MRW7B4AD (3-Iodobenzylguanidine)
SB  - IM
MH  - *3-Iodobenzylguanidine
MH  - Aged
MH  - Diagnosis, Differential
MH  - Female
MH  - Humans
MH  - Iodine Radioisotopes
MH  - Male
MH  - Middle Aged
MH  - Multiple System Atrophy/complications/*diagnosis
MH  - Myocardial Perfusion Imaging
MH  - Olfaction Disorders/diagnosis/etiology
MH  - Parkinson Disease/complications/*diagnosis
MH  - *Radiopharmaceuticals
MH  - Sensitivity and Specificity
EDAT- 2011/08/16 06:00
MHDA- 2012/02/09 06:00
CRDT- 2011/08/16 06:00
PHST- 2011/03/01 00:00 [received]
PHST- 2011/06/21 00:00 [revised]
PHST- 2011/07/26 00:00 [accepted]
PHST- 2011/08/16 06:00 [entrez]
PHST- 2011/08/16 06:00 [pubmed]
PHST- 2012/02/09 06:00 [medline]
AID - S1353-8020(11)00230-6 [pii]
AID - 10.1016/j.parkreldis.2011.07.011 [doi]
PST - ppublish
SO  - Parkinsonism Relat Disord. 2011 Nov;17(9):698-700. doi: 
      10.1016/j.parkreldis.2011.07.011. Epub 2011 Aug 12.