PMID- 21840299
OWN - NLM
STAT- MEDLINE
DCOM- 20111122
LR  - 20211020
IS  - 1090-2104 (Electronic)
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 412
IP  - 4
DP  - 2011 Sep 9
TI  - CXCL8 protects human neurons from amyloid-beta-induced neurotoxicity: relevance to 
      Alzheimer's disease.
PG  - 565-71
LID - 10.1016/j.bbrc.2011.07.127 [doi]
AB  - Alzheimer's disease (AD) is a neurodegenerative disease characterized by 
      amyloid-beta (Abeta) deposition in senile plaques colocalized with activated microglia 
      and astrocytes. Recent studies suggest that CXCL8 is involved in the AD 
      pathogenesis. The objective of this study was to determine the cellular sources 
      of CXCL8 in the central nervous system during AD pathogenesis, and investigate 
      the effects of CXCL8 on neuronal survival and/or functions. Our results showed 
      significantly higher CXCL8 levels in AD brain tissue lysates as compared to those 
      of age-matched controls. Upon Abeta and/or pro-inflammatory cytokine stimulation, 
      microglia, astrocytes and neurons were all capable of CXCL8 production in vitro. 
      Although CXCL8-alone did not alter neuronal survival, it did inhibit Abeta-induced 
      neuronal apoptosis and increased neuronal brain-derived neurotrophic factor 
      (BDNF) production. We conclude that microglia, astrocytes and neurons, all 
      contribute to the enhanced CXCL8 levels in the CNS upon Abeta and/or 
      pro-inflammatory cytokine stimulation. Further, CXCL8 protects neurons possibly 
      by paracrine or autocrine loop and regulates neuronal functions, therefore, may 
      play a protective role in the AD pathogenesis.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Ashutosh
AU  - Ashutosh
AD  - Department of Cell Biology and Anatomy, University of North Texas Health Science 
      Center, Fort Worth, TX 76107, USA.
FAU - Kou, Wei
AU  - Kou W
FAU - Cotter, Robin
AU  - Cotter R
FAU - Borgmann, Kathleen
AU  - Borgmann K
FAU - Wu, Li
AU  - Wu L
FAU - Persidsky, Raisa
AU  - Persidsky R
FAU - Sakhuja, Namita
AU  - Sakhuja N
FAU - Ghorpade, Anuja
AU  - Ghorpade A
LA  - eng
GR  - U01 MH083506-05/MH/NIMH NIH HHS/United States
GR  - R24 MH059724/MH/NIMH NIH HHS/United States
GR  - R24 NS038841-10/NS/NINDS NIH HHS/United States
GR  - R24 NS038841/NS/NINDS NIH HHS/United States
GR  - U01 MH083500-05/MH/NIMH NIH HHS/United States
GR  - R24 NS45491/NS/NINDS NIH HHS/United States
GR  - N01 MH032002/MH/NIMH NIH HHS/United States
GR  - U01MH083501/MH/NIMH NIH HHS/United States
GR  - U01 MH083501/MH/NIMH NIH HHS/United States
GR  - R24 HD000836/HD/NICHD NIH HHS/United States
GR  - U01 MH083506/MH/NIMH NIH HHS/United States
GR  - U01MH083507/MH/NIMH NIH HHS/United States
GR  - R01 NS048837-01A1/NS/NINDS NIH HHS/United States
GR  - U01MH083545/MH/NIMH NIH HHS/United States
GR  - NS38841/NS/NINDS NIH HHS/United States
GR  - U24 MH100929/MH/NIMH NIH HHS/United States
GR  - U01 MH083507/MH/NIMH NIH HHS/United States
GR  - R01 MH087345/MH/NIMH NIH HHS/United States
GR  - R24 MH059745-10/MH/NIMH NIH HHS/United States
GR  - U01 MH083500/MH/NIMH NIH HHS/United States
GR  - U24 MH100931/MH/NIMH NIH HHS/United States
GR  - 5R24HD0008836/HD/NICHD NIH HHS/United States
GR  - R24 HD000836-47/HD/NICHD NIH HHS/United States
GR  - R24 NS045491/NS/NINDS NIH HHS/United States
GR  - N01MH32002/MH/NIMH NIH HHS/United States
GR  - R24 NS045491-10/NS/NINDS NIH HHS/United States
GR  - R01 MH087345-01/MH/NIMH NIH HHS/United States
GR  - R01 NS48837/NS/NINDS NIH HHS/United States
GR  - 5U01MH083500/MH/NIMH NIH HHS/United States
GR  - U01 MH083545-05/MH/NIMH NIH HHS/United States
GR  - R24MH59724/MH/NIMH NIH HHS/United States
GR  - R24 MH059745/MH/NIMH NIH HHS/United States
GR  - R24MH59745/MH/NIMH NIH HHS/United States
GR  - R01 NS048837/NS/NINDS NIH HHS/United States
GR  - U01 MH083501-05/MH/NIMH NIH HHS/United States
GR  - U01MH083506/MH/NIMH NIH HHS/United States
GR  - U01 MH083545/MH/NIMH NIH HHS/United States
GR  - MH087345/MH/NIMH NIH HHS/United States
GR  - Z01 HD008836/ImNIH/Intramural NIH HHS/United States
GR  - U01 MH083507-05/MH/NIMH NIH HHS/United States
GR  - R24 MH059724-10/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110805
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Interleukin-8)
RN  - 0 (Peptide Fragments)
RN  - 0 (amyloid beta-protein (1-42))
SB  - IM
MH  - Alzheimer Disease/metabolism/*pathology
MH  - Amyloid beta-Peptides/*metabolism/toxicity
MH  - Apoptosis/drug effects
MH  - Astrocytes/metabolism/pathology
MH  - Brain/metabolism/*pathology
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cells, Cultured
MH  - Humans
MH  - Interleukin-8/*metabolism
MH  - Neurons/drug effects/metabolism/*pathology
MH  - Peptide Fragments/*metabolism/toxicity
PMC - PMC3236067
MID - NIHMS323105
EDAT- 2011/08/16 06:00
MHDA- 2011/12/13 00:00
PMCR- 2012/09/09
CRDT- 2011/08/16 06:00
PHST- 2011/07/22 00:00 [received]
PHST- 2011/07/28 00:00 [accepted]
PHST- 2011/08/16 06:00 [entrez]
PHST- 2011/08/16 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
PHST- 2012/09/09 00:00 [pmc-release]
AID - S0006-291X(11)01371-4 [pii]
AID - 10.1016/j.bbrc.2011.07.127 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2011 Sep 9;412(4):565-71. doi: 
      10.1016/j.bbrc.2011.07.127. Epub 2011 Aug 5.