PMID- 21840597
OWN - NLM
STAT- MEDLINE
DCOM- 20120103
LR  - 20221207
IS  - 1873-5835 (Electronic)
IS  - 0145-2126 (Linking)
VI  - 35
IP  - 12
DP  - 2011 Dec
TI  - Meta-analysis of human leukocyte antigen genetic polymorphisms and susceptibility 
      to chronic myelogenous leukemia in Chinese population.
PG  - 1564-70
LID - 10.1016/j.leukres.2011.07.018 [doi]
AB  - Human leukocyte antigen (HLA) genetic polymorphisms are assumed to be correlated 
      to the risk of chronic myelogenous leukemia (CML) in various ethnicities. Up to 
      now, no clear consensus has been reached. Our goal is to address this issue in 
      Chinese population. By searching the data in PubMed, Embase and four Chinese 
      databases (prior to July 2010), the association of HLA genetic polymorphisms with 
      CML has been fixed as the research objective. We studied a totality of 12 
      studies, comprising 2281 CML cases and 41000 health controls. The data 
      demonstrated that HLA-A*11, A*74, HLA-B*40, B*47, B*55 and B*81 alleles were 
      correlated with the increasing risk of CML. Nevertheless, HLA-DRB1*13 allele 
      seemed to contribute to the genetic protection to CML. Conclusively we suggested 
      that certain HLA alleles might be in association with the pathogenesis of CML in 
      Chinese population. Due to little statistical scale, larger studies and 
      particularly in a mono-people background, our hypothesis need to be further 
      investigated in the future.
CI  - Copyright A(c) 2011 Elsevier Ltd. All rights reserved.
FAU - Zhang, Min-Yue
AU  - Zhang MY
AD  - Department of Hematology, Ren Ji Hospital, Shanghai Jiaotong University School of 
      Medicine, Shaghai, People's Republic of China.
FAU - Chen, Fang-Yuan
AU  - Chen FY
FAU - Zhong, Hua
AU  - Zhong H
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20110815
PL  - England
TA  - Leuk Res
JT  - Leukemia research
JID - 7706787
RN  - 0 (HLA Antigens)
SB  - IM
CIN - Leuk Res. 2011 Dec;35(12):1545-6. PMID: 21839514
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Algorithms
MH  - Asian People/*genetics
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Databases as Topic/statistics & numerical data
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genetics, Population
MH  - HLA Antigens/*genetics
MH  - Humans
MH  - Infant
MH  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive/ethnology/*genetics
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Genetic/physiology
MH  - Young Adult
EDAT- 2011/08/16 06:00
MHDA- 2012/01/04 06:00
CRDT- 2011/08/16 06:00
PHST- 2011/04/18 00:00 [received]
PHST- 2011/07/09 00:00 [revised]
PHST- 2011/07/11 00:00 [accepted]
PHST- 2011/08/16 06:00 [entrez]
PHST- 2011/08/16 06:00 [pubmed]
PHST- 2012/01/04 06:00 [medline]
AID - S0145-2126(11)00365-1 [pii]
AID - 10.1016/j.leukres.2011.07.018 [doi]
PST - ppublish
SO  - Leuk Res. 2011 Dec;35(12):1564-70. doi: 10.1016/j.leukres.2011.07.018. Epub 2011 
      Aug 15.