PMID- 21842410
OWN - NLM
STAT- MEDLINE
DCOM- 20120626
LR  - 20211020
IS  - 1432-1106 (Electronic)
IS  - 0014-4819 (Print)
IS  - 0014-4819 (Linking)
VI  - 214
IP  - 2
DP  - 2011 Oct
TI  - Gaze shift duration, independent of amplitude, influences the number of spikes in 
      the burst for medium-lead burst neurons in pontine reticular formation.
PG  - 225-39
LID - 10.1007/s00221-011-2823-8 [doi]
AB  - Changes in the direction of the line of sight (gaze) allow successive sampling of 
      the visual environment. Saccadic eye movements accomplish this goal when the head 
      does not move. Medium-lead burst neurons (MLBs) in the paramedian pontine 
      reticular formation (PPRF) discharge a high frequency burst of action potentials 
      starting ~12 ms before the saccade begins. A subgroup of MLBs rostral of abducens 
      nucleus monosynaptically excites oculomotor neurons. The number of spikes in the 
      presaccadic burst is correlated with the amplitude of the horizontal component of 
      the saccade, and the peak discharge rate is correlated with peak eye velocity. 
      During head-unrestrained gaze shifts, a linear relationship between the number of 
      action potentials in MLB bursts and gaze (but not eye) amplitude has been 
      reported. The anatomical connection of MLBs to motor neurons and the similarity 
      between the phasic motor neuron burst and MLB discharge have raised questions 
      about the usefulness of counting spikes in MLBs to determine their role in 
      eye-head coordination. We investigated this issue using a behavioral technique 
      that permits a dissociation of eye movement amplitude and duration during 
      constant vector gaze shifts. Surprisingly, during gaze shifts of constant 
      amplitude and direction, we observe a nearly linear, positive correlation between 
      saccade duration and spike number associated with a negative correlation between 
      spike number and saccade amplitude. These data constrain models of the oculomotor 
      controller and may further define the time-dependence of hypothesized neural 
      integration in this system.
FAU - Walton, Mark M G
AU  - Walton MM
AD  - Department of Neurobiology and Anatomy, School of Medicine and Dentistry, 
      University of Rochester, 601 Elmwood Ave., Box 603, Rochester, NY 14642, USA. 
      Mark_Walton@urmc.rochester.edu
FAU - Freedman, Edward G
AU  - Freedman EG
LA  - eng
GR  - R01 EY013239/EY/NEI NIH HHS/United States
GR  - EY 13239/EY/NEI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110814
PL  - Germany
TA  - Exp Brain Res
JT  - Experimental brain research
JID - 0043312
SB  - IM
MH  - Action Potentials/*physiology
MH  - Animals
MH  - Female
MH  - Head Movements/physiology
MH  - Macaca mulatta
MH  - Neurons/*physiology
MH  - Pons/cytology/*physiology
MH  - Psychomotor Performance/physiology
MH  - Reticular Formation/*physiology
MH  - Saccades/*physiology
MH  - Time Factors
PMC - PMC5057534
MID - NIHMS487621
EDAT- 2011/08/16 06:00
MHDA- 2012/06/27 06:00
PMCR- 2016/10/11
CRDT- 2011/08/16 06:00
PHST- 2011/04/08 00:00 [received]
PHST- 2011/07/29 00:00 [accepted]
PHST- 2011/08/16 06:00 [entrez]
PHST- 2011/08/16 06:00 [pubmed]
PHST- 2012/06/27 06:00 [medline]
PHST- 2016/10/11 00:00 [pmc-release]
AID - 10.1007/s00221-011-2823-8 [doi]
PST - ppublish
SO  - Exp Brain Res. 2011 Oct;214(2):225-39. doi: 10.1007/s00221-011-2823-8. Epub 2011 
      Aug 14.