PMID- 21843913
OWN - NLM
STAT- MEDLINE
DCOM- 20111108
LR  - 20111117
IS  - 1872-7980 (Electronic)
IS  - 0304-3835 (Linking)
VI  - 311
IP  - 2
DP  - 2011 Dec 8
TI  - Human leukocyte antigen-G in cancer: are they clinically relevant?
PG  - 123-30
LID - 10.1016/j.canlet.2011.07.019 [doi]
AB  - The immunotolerant human leukocyte antigen (HLA)-G has direct inhibitory effects 
      on natural killer cells (NK), dendritic cells (DC), T cells and can induce 
      tolerant regulatory cells. The expression of HLA-G has been correlated with the 
      tolerance of the fetus, the acceptance of organ transplants, and the immune 
      escape of tumor cells and virus-infected cells. In the context of malignancies, 
      aberrant induction of HLA-G expression has been extensively investigated and its 
      clinical relevance has been postulated. We here focus on the HLA-G expression in 
      malignancies and its relevance to tumor cell immune escaping and disease 
      progression.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Yan, Wei-Hua
AU  - Yan WH
AD  - Medical Research Center, Taizhou Hospital of Zhejiang Province, Wenzhou Medical 
      College, Linhai, Zhejiang, People's Republic of China. yanwhcom@yahoo.com
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110722
PL  - Ireland
TA  - Cancer Lett
JT  - Cancer letters
JID - 7600053
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - HLA Antigens/*immunology
MH  - HLA-G Antigens
MH  - Histocompatibility Antigens Class I/*immunology
MH  - Humans
MH  - Neoplasms/*immunology
MH  - Tumor Escape/*immunology
EDAT- 2011/08/17 06:00
MHDA- 2011/11/09 06:00
CRDT- 2011/08/17 06:00
PHST- 2011/06/09 00:00 [received]
PHST- 2011/07/13 00:00 [revised]
PHST- 2011/07/14 00:00 [accepted]
PHST- 2011/08/17 06:00 [entrez]
PHST- 2011/08/17 06:00 [pubmed]
PHST- 2011/11/09 06:00 [medline]
AID - S0304-3835(11)00433-2 [pii]
AID - 10.1016/j.canlet.2011.07.019 [doi]
PST - ppublish
SO  - Cancer Lett. 2011 Dec 8;311(2):123-30. doi: 10.1016/j.canlet.2011.07.019. Epub 
      2011 Jul 22.