PMID- 21844975
OWN - NLM
STAT- MEDLINE
DCOM- 20120524
LR  - 20171116
IS  - 1671-167X (Print)
IS  - 1671-167X (Linking)
VI  - 43
IP  - 4
DP  - 2011 Aug 18
TI  - [Levels of interlukin-6 and tumor necrosis factor-alpha in saliva of patients with 
      type 2 diabetes mellitus and oral lichen planus].
PG  - 596-9
AB  - OBJECTIVE: To study the relationship between type 2 diabetes mellitus (T2DM) and 
      oral lichen planus (OLP) by detecting the level of salivary tumor necrosis factor 
      (TNF-alpha) and interlukin-6 (IL-6). METHODS: Subjects were divided into 4 groups: 
      T2DM/OLP group 29 patients, T2DM group 39 patients, OLP group 21 patients, and 
      control group 43 individuals. The salivary interleukin-6 (IL-6) and tumor 
      necrosis factor (TNF-alpha) were detected by enzyme-linked immuno sorbent assay 
      (ELISA). RESULTS: (1) The level of salivary IL-6 in patients with T2DM/OLP 
      [(12.30 +/- 16.03) ng/L] was significantly higher than those in T2DM [(6.29 +/- 5.91) 
      ng/L] and OLP groups [(3.64 +/- 4.47) ng/L], P<0.05. The level of salivary IL-6 was 
      significantly lower in OLP group [(3.64 +/- 4.47) ng/L] than in control group 
      [(7.91 +/- 4.05) ng/L], P<0.001. The level of salivary TNF-alpha in T2DM group [(8.80 +/- 
      8.41) ng/L] was significantly lower than those in OLP [(14.02 +/- 9.65) ng/L] and 
      control groups [(15.02 +/- 6.13) ng/L], P<0.05. (2) The level of salivary TNF-alpha is 
      significantly negative correlated with pH value of saliva in T2DM/OLP 
      group(r=-0.593, P<0.01);The level of salivary TNF-alpha and IL-6 are significantly 
      positive correlated with waistline in control group(r=0.312,P=0.05).(3) The 
      levels of salivary IL-6 and TNF-alpha were positively related to OLP clinical type, 
      P<0.05. (4)When OLP played an overlying role on T2DM, the level of TNF-alpha was 
      weakened and that of IL-6 was strengthened. CONCLUSION: When T2DM and OLP are in 
      concurrence,there is a synergistic effect,and the secretion of IL-6 increases 
      markedly; The level of salivary TNF-alpha is associated with local oral environment.
FAU - Liu, Yang
AU  - Liu Y
AD  - Department of TCM and Oral Medicine, Peking University School and Hospital of 
      Stomatology, Beijing 100081, China.
FAU - Jin, Jian-qiu
AU  - Jin JQ
FAU - Yuan, Zhen-fang
AU  - Yuan ZF
FAU - Liu, Xiao Song
AU  - Liu XS
FAU - Cao, Jie
AU  - Cao J
FAU - Guo, Xiao-hui
AU  - Guo XH
FAU - Liu, Hong-wei
AU  - Liu HW
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Beijing Da Xue Xue Bao Yi Xue Ban
JT  - Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health 
      sciences
JID - 101125284
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Aged
MH  - Diabetes Mellitus, Type 2/complications/*metabolism
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Interleukin-6/*analysis
MH  - Lichen Planus, Oral/complications/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Saliva/*chemistry
MH  - Tumor Necrosis Factor-alpha/*analysis
EDAT- 2011/08/17 06:00
MHDA- 2012/05/25 06:00
CRDT- 2011/08/17 06:00
PHST- 2011/08/17 06:00 [entrez]
PHST- 2011/08/17 06:00 [pubmed]
PHST- 2012/05/25 06:00 [medline]
PST - ppublish
SO  - Beijing Da Xue Xue Bao Yi Xue Ban. 2011 Aug 18;43(4):596-9.