PMID- 21845828
OWN - NLM
STAT- MEDLINE
DCOM- 20111128
LR  - 20110817
IS  - 2096-7993 (Print)
IS  - 2096-7993 (Linking)
VI  - 25
IP  - 11
DP  - 2011 Jun
TI  - [Expression of microtubule-associated protein 1 light chain 3 in laryngeal 
      carcinoma].
PG  - 497-500
AB  - OBJECTIVE: To investigate the expression of microtuble-associated protein 1 light 
      chain 3 (LC3) in laryngeal squamous cell carcinoma (LSCC). METHOD: The expression 
      of LC3 in 50 cases of LSCC, 45 cases of para-carcinoma, 10 cases of laryngeal 
      papilloma and 16 cases of polyp of vocal cord were detected by 
      immunohistochemistry (MaxVision method). Expression level of LC3 mRNA was assayed 
      by RT-PCR in 41 of LSCC, 41 of para-carcinoma tissue and 11 of polyp of vocal 
      cord. RESULT: The positive rates of LC3 protein expression were 60.0%, 93.3%, 
      90.0%, 93.8% in LSCC tissue, para-carcinoma, laryngeal papilloma and poly of 
      vocal card tissues, respectively. The positive rates of LC3 were significantly 
      lower in LSCC than in para-carcinoma and poly of vocal cord (chi2 = 18.135, P < 
      0.01). The mRNA levels of LC3 were significantly lower in LSCC than in 
      para-carcinoma and poly of vocal cord (0.57 +/- 0.08 )vs (0.99 +/- 0.11) and 
      (1.07 +/- 0.05) , F = -255.872, P < 0.01. The expression of LC3 were related to 
      tumor location and pathological grade (P < 0.05), but not related to age, T 
      stage, clinical stage and lymphoid metastasis (P > 0.05). CONCLUSION: Expression 
      of LC3 are down-regulated in LSCC. The change of autophagic capacity may play an 
      important role in occurrence and development of LSCC.
FAU - Wan, Baoluo
AU  - Wan B
AD  - Department of Otorhinolaryngology, Union Hospital, Tongji Medical 
      College,Huazhong University of Science and Technology, Wuhan 430022, China.
FAU - Dong, Junhua
AU  - Dong J
FAU - Wang, Lin
AU  - Wang L
FAU - Zhang, Sulin
AU  - Zhang S
FAU - Kong, Weijia
AU  - Kong W
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical 
      otorhinolaryngology, head, and neck surgery
JID - 101303164
RN  - 0 (MAP1LC3A protein, human)
RN  - 0 (Microtubule-Associated Proteins)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Squamous Cell/*metabolism/pathology
MH  - Female
MH  - Humans
MH  - Laryngeal Neoplasms/*metabolism/pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Microtubule-Associated Proteins/genetics/*metabolism
MH  - Middle Aged
MH  - Neoplasm Staging
EDAT- 2011/08/19 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/08/18 06:00
PHST- 2011/08/18 06:00 [entrez]
PHST- 2011/08/19 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2011 Jun;25(11):497-500.