PMID- 21845837
OWN - NLM
STAT- MEDLINE
DCOM- 20130110
LR  - 20110817
IS  - 1000-3061 (Print)
IS  - 1000-3061 (Linking)
VI  - 27
IP  - 5
DP  - 2011 May
TI  - [Mechanism of intravenous immunoglobulin therapy for severe hand-foot-mouth 
      disease: a review].
PG  - 712-6
AB  - Hand-foot-mouth disease (HFMD) is an acute infectious disease caused by various 
      enteroviruses. Recently, large HFMD outbreaks caused by enterovirus type 71 
      (EV71) have been frequently reported in China, posing great threats on children's 
      health. There is no specific antiviral therapy for severe HFMD, and patient 
      management mainly depends on supportive and symptomatic treatment. Intravenous 
      immunoglobulin (IVIG) is a pharmaceutical preparation of human IgG that is pooled 
      from thousands of healthy blood donors, and contained neutralization antibodies 
      against various enteroviruses, including EV71. IVIG therapy should be carefully 
      administrated for severe HFMD considering its role on passive immunization 
      against EV71 and immune regulation.
FAU - Cao, Ruiyuan
AU  - Cao R
AD  - State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of 
      Microbiology and Epidemiologv, Beijing 100071, China.
FAU - Han, Jianfeng
AU  - Han J
FAU - Qin, Ede
AU  - Qin E
FAU - Qin, Chengfeng
AU  - Qin C
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - China
TA  - Sheng Wu Gong Cheng Xue Bao
JT  - Sheng wu gong cheng xue bao = Chinese journal of biotechnology
JID - 9426463
RN  - 0 (Antibodies, Neutralizing)
RN  - 0 (Antibodies, Viral)
RN  - 0 (Immunoglobulins, Intravenous)
SB  - IM
MH  - Antibodies, Neutralizing/immunology/therapeutic use
MH  - Antibodies, Viral/immunology/therapeutic use
MH  - Enterovirus A, Human/immunology
MH  - Hand, Foot and Mouth Disease/*therapy/virology
MH  - Humans
MH  - *Immunization, Passive
MH  - Immunoglobulins, Intravenous/immunology/*therapeutic use
EDAT- 2011/08/19 06:00
MHDA- 2013/01/11 06:00
CRDT- 2011/08/18 06:00
PHST- 2011/08/18 06:00 [entrez]
PHST- 2011/08/19 06:00 [pubmed]
PHST- 2013/01/11 06:00 [medline]
PST - ppublish
SO  - Sheng Wu Gong Cheng Xue Bao. 2011 May;27(5):712-6.