PMID- 21847984
OWN - NLM
STAT- MEDLINE
DCOM- 20120802
LR  - 20190923
IS  - 1000-8713 (Print)
IS  - 1000-8713 (Linking)
VI  - 29
IP  - 5
DP  - 2011 May
TI  - [Simultaneous determination of 3 benzalkonium chloride homologs in cosmetics by 
      high performance liquid chromatography].
PG  - 458-61
AB  - An analytical method based on high performance liquid chromatography with a diode 
      array detector (HPLC-DAD) has been established for the simultaneous determination 
      of 3 benzalkonium chloride homologs (n-C12H25-C9H13NCl, n-C14H29-C9H13NCl, 
      n-C16,H33-C9H13NCl) in cosmetics. The sample was extracted with methanol 
      (including 0.5% formic acid) under ultrasonic operation, the HPLC separation was 
      carried out on a CAPCELL PAK SCX column (250 mm x 4.6 mm, 5 microm), the mobile 
      phases were 40 mmol/L ammonium acetate solution (including 0.1% triethylamine) 
      and acetonitrile with gradient elution, the flow rate was 1.0 mL/min, the 
      detection wavelength was 260 nm, the column temperature was 25 degrees C, and the 
      injection volume was 20 microL. The limit of detection was 50.0 mg/kg and the 
      quantitation limit was 200.0 mg/kg for 3 benzalkonium chloride homologs in 
      cosmetics. The linear plots were obtained between 5.0 mg/L and 3000.0 mg/L. 
      Overall recoveries were between 92.5% and 102.1% with the relative standard 
      deviations (RSDs) between 3.81% and 6.66%. The method is simple, rapid, accurate 
      and suitable for the determination of 3 benzalkonium chloride homologs in 
      cosmetics.
FAU - Liu, Yanqin
AU  - Liu Y
AD  - Haidian District Institute of Products Quality Supervision and Inspection, 
      Beijing 100094, China.
FAU - Wang, Hao
AU  - Wang H
FAU - Yang, Hongmei
AU  - Yang H
FAU - Shi, Hailiang
AU  - Shi H
FAU - Guo, Qilei
AU  - Guo Q
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Se Pu
JT  - Se pu = Chinese journal of chromatography
JID - 9424804
RN  - 0 (Benzalkonium Compounds)
RN  - 0 (Cosmetics)
SB  - IM
MH  - Benzalkonium Compounds/*analysis
MH  - Chromatography, High Pressure Liquid/*methods
MH  - Cosmetics/*analysis
EDAT- 2011/08/19 06:00
MHDA- 2012/08/03 06:00
CRDT- 2011/08/19 06:00
PHST- 2011/08/19 06:00 [entrez]
PHST- 2011/08/19 06:00 [pubmed]
PHST- 2012/08/03 06:00 [medline]
AID - 10.3724/sp.j.1123.2011.00458 [doi]
PST - ppublish
SO  - Se Pu. 2011 May;29(5):458-61. doi: 10.3724/sp.j.1123.2011.00458.