PMID- 21849368
OWN - NLM
STAT- MEDLINE
DCOM- 20111014
LR  - 20211020
IS  - 1748-880X (Electronic)
IS  - 0007-1285 (Print)
IS  - 0007-1285 (Linking)
VI  - 84
IP  - 1005
DP  - 2011 Sep
TI  - MRI-based pre-planning in patients with cervical cancer treated with 
      three-dimensional brachytherapy.
PG  - 850-6
LID - 10.1259/bjr/75446993 [doi]
AB  - OBJECTIVE: The aim of this study was to analyse the feasibility and determine the 
      benefits of MRI-based pre-planning with CT/MRI data fusion in patients with 
      cervical cancer treated with radical radiotherapy. METHODS: Patients underwent 
      MRI examination prior to external beam radiotherapy and prior to the first and 
      fourth fraction of brachytherapy with applicators in place. Insertion of 
      applicators at the radiology department was performed under paracervical 
      anaesthesia. The benefit of MRI pre-planning was determined by comparing 
      conventional treatment planning with dose specification to "point A" and dose 
      specification to 90% of the high-risk clinical target volume (HR-CTV D90). 
      Tolerance of MRI evaluation with applicators, coverage of HR-CTV and dose-volume 
      parameters for organs at risk (OAR) has been assessed in 42 brachytherapy 
      procedures. RESULTS: Insertion of applicators at the radiology department was 
      successful in all patients and there were no complications. The target dose was 
      higher for MRI planning than for conventional planning (5.3 Gy vs 4.5 Gy). 
      Maximum doses in the bladder and rectum were significantly lower (p<0.05) for MRI 
      planning than for the conventional approach (6.49 Gy vs 7.45 Gy for bladder; 4.57 
      Gy vs 5.06 Gy for rectum). We found no correlation between the International 
      Commission on Radiation Units (ICRU) point dose for OAR and the maximum dose in 
      OAR. Nevertheless, a strong correlation between the maximum dose in OAR and the 
      minimal dose in a volume of 2 cm(3) has been observed. CONCLUSION: MRI-based 
      pre-planning with consecutive CT/MRI data fusion is feasible and safe, with the 
      advantage of increasing the dose to the tumour and decreasing the dose to the 
      organs at risk.
FAU - Dolezel, M
AU  - Dolezel M
AD  - Oncology Centre, Pardubice Regional Hospital, Pardubice, Czech Republic. 
      dolezelm@email.cz
FAU - Odrazka, K
AU  - Odrazka K
FAU - Vanasek, J
AU  - Vanasek J
FAU - Kohlova, T
AU  - Kohlova T
FAU - Kroulik, T
AU  - Kroulik T
FAU - Kudelka, K
AU  - Kudelka K
FAU - Spitzer, D
AU  - Spitzer D
FAU - Mrklovsky, M
AU  - Mrklovsky M
FAU - Tichy, M
AU  - Tichy M
FAU - Zizka, J
AU  - Zizka J
FAU - Jalcova, L
AU  - Jalcova L
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PL  - England
TA  - Br J Radiol
JT  - The British journal of radiology
JID - 0373125
SB  - IM
MH  - Brachytherapy/*methods
MH  - Feasibility Studies
MH  - Female
MH  - Humans
MH  - *Magnetic Resonance Imaging
MH  - Organs at Risk
MH  - Radiotherapy Dosage
MH  - Radiotherapy Planning, Computer-Assisted/*methods
MH  - Rectum/pathology/*radiation effects
MH  - Tomography, X-Ray Computed
MH  - Urinary Bladder/pathology/*radiation effects
MH  - Uterine Cervical Neoplasms/*diagnosis/pathology/radiotherapy
PMC - PMC3473781
EDAT- 2011/08/19 06:00
MHDA- 2011/10/15 06:00
PMCR- 2012/09/01
CRDT- 2011/08/19 06:00
PHST- 2011/08/19 06:00 [entrez]
PHST- 2011/08/19 06:00 [pubmed]
PHST- 2011/10/15 06:00 [medline]
PHST- 2012/09/01 00:00 [pmc-release]
AID - 84/1005/850 [pii]
AID - D10446 [pii]
AID - 10.1259/bjr/75446993 [doi]
PST - ppublish
SO  - Br J Radiol. 2011 Sep;84(1005):850-6. doi: 10.1259/bjr/75446993.