PMID- 21849416
OWN - NLM
STAT- MEDLINE
DCOM- 20140514
LR  - 20140730
IS  - 1469-994X (Electronic)
IS  - 1462-2203 (Linking)
VI  - 13
IP  - 11
DP  - 2011 Nov
TI  - GSTM1 modifies the effect of maternal exposure to environmental tobacco smoke on 
      neonatal primitive reflexes.
PG  - 1114-22
LID - 10.1093/ntr/ntr124 [doi]
AB  - OBJECTIVE: The aim of this study was to examine whether infant metabolic gene 
      polymorphisms modify the effect of maternal environmental tobacco smoke (ETS) on 
      neonatal neurobehavior. METHODS: We conducted a birth cohort study of 87 
      nonsmoking women who delivered single births of normal birth weight. We enrolled 
      the women before delivery, interviewed them using a structured questionnaire, and 
      collected umbilical cord blood. Umbilical cord cotinine, a blood indicator of 
      prenatal ETS exposure, was analyzed. The Neonatal Neurobehavioral 
      Examination-Chinese Version (NNE-C) was administrated within 5 days after 
      delivery to examine neonatal neurobehavior. Four infant metabolic genes, CYP1A1 
      MspI, CYP1A1 Ile462Val, GSTT1, and GSTM1, were identified. RESULTS: Maternal ETS 
      exposure during pregnancy was not related to neonatal neurobehavior when infant 
      genetic polymorphisms were not considered. However, maternal ETS exposure did 
      cause adverse effects in neonates with the absent type of GSTM1. Adverse effects 
      were seen on the total NNE-C (beta = -2.55; p = .02) and on primitive reflexes (beta = 
      -1.70; p = .004), especially in grasp reflexes (beta = -.36; p = .011) and tonic 
      neck reflexes (beta = -.36; p = .049). In addition, there was a significant 
      interaction between maternal ETS exposure and infant GSTM1 genotype on neonate 
      grasp reflexes (p for interaction = .019). CONCLUSIONS: These data indicate that 
      weaker responses in neonatal primitive reflexes in infants with the absent type 
      GSTM1 were related to maternal ETS exposure during pregnancy.
FAU - Hsieh, Chia-Jung
AU  - Hsieh CJ
AD  - Institute of Occupational Medicine and Industrial Hygiene, National Taiwan 
      University College of Public Health, Taipei, Taiwan.
FAU - Jeng, Suh-Fang
AU  - Jeng SF
FAU - Wu, Kuen-Yuh
AU  - Wu KY
FAU - Su, Yi-Ning
AU  - Su YN
FAU - Liao, Hua-Fang
AU  - Liao HF
FAU - Hsieh, Wu-Shiun
AU  - Hsieh WS
FAU - Chen, Pau-Chung
AU  - Chen PC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110817
PL  - England
TA  - Nicotine Tob Res
JT  - Nicotine & tobacco research : official journal of the Society for Research on 
      Nicotine and Tobacco
JID - 9815751
RN  - 0 (Tobacco Smoke Pollution)
RN  - EC 1.14.14.1 (Cytochrome P-450 CYP1A1)
RN  - EC 2.5.1.- (glutathione S-transferase T1)
RN  - EC 2.5.1.18 (Glutathione Transferase)
RN  - EC 2.5.1.18 (glutathione S-transferase M1)
RN  - K5161X06LL (Cotinine)
SB  - IM
MH  - Adult
MH  - Birth Weight
MH  - Case-Control Studies
MH  - Cohort Studies
MH  - Cotinine/blood
MH  - Cytochrome P-450 CYP1A1/genetics
MH  - Female
MH  - Fetal Blood/chemistry
MH  - Genotype
MH  - Glutathione Transferase/*genetics
MH  - Humans
MH  - Infant, Newborn
MH  - Linear Models
MH  - Maternal Exposure/*adverse effects
MH  - Polymorphism, Genetic/*genetics
MH  - Pregnancy
MH  - Prospective Studies
MH  - Reflex/*genetics
MH  - Taiwan
MH  - Tobacco Smoke Pollution/*adverse effects
MH  - Young Adult
EDAT- 2011/08/19 06:00
MHDA- 2014/05/16 06:00
CRDT- 2011/08/19 06:00
PHST- 2011/08/19 06:00 [entrez]
PHST- 2011/08/19 06:00 [pubmed]
PHST- 2014/05/16 06:00 [medline]
AID - ntr124 [pii]
AID - 10.1093/ntr/ntr124 [doi]
PST - ppublish
SO  - Nicotine Tob Res. 2011 Nov;13(11):1114-22. doi: 10.1093/ntr/ntr124. Epub 2011 Aug 
      17.