PMID- 21849458
OWN - NLM
STAT- MEDLINE
DCOM- 20111107
LR  - 20211020
IS  - 1098-5514 (Electronic)
IS  - 0022-538X (Print)
IS  - 0022-538X (Linking)
VI  - 85
IP  - 20
DP  - 2011 Oct
TI  - Human leukocyte antigen genotype and risk of HIV disease progression before and 
      after initiation of antiretroviral therapy.
PG  - 10826-33
LID - 10.1128/JVI.00804-11 [doi]
AB  - While the human leukocyte antigen (HLA) genotype has been associated with the 
      rate of HIV disease progression in untreated patients, little is known regarding 
      these relationships in patients using highly active antiretroviral therapy 
      (HAART). The limited data reported to date identified few HLA-HIV disease 
      associations in patients using HAART and even occasional associations that were 
      opposite of those found in untreated patients. We conducted high-resolution HLA 
      class I and II genotyping in a random sample (n = 860) of HIV-seropositive women 
      enrolled in a long-term cohort initiated in 1994. HLA-HIV disease associations 
      before and after initiation of HAART were examined using multivariate analyses. 
      In untreated HIV-seropositive patients, we observed many of the predicted 
      associations, consistent with prior studies. For example, HLA-B*57 (beta = -0.7; 95% 
      confidence interval [CI] = -0.9 to -0.5; P = 5 x 10(-)(1)(1)) and Bw4 (beta = -0.2; 95% CI 
      = -0.4 to -0.1; P = 0.009) were inversely associated with baseline HIV viral 
      load, and B*57 was associated with a low risk of rapid CD4+ decline (odds ratio 
      [OR] = 0.2; 95% CI = 0.1 to 0.6; P = 0.002). Conversely, in treated patients, the 
      odds of a virological response to HAART were lower for B*57:01 (OR = 0.2; 95% CI 
      = 0.0 to 0.9; P = 0.03), and Bw4 (OR = 0.4; 95% CI = 0.1 to 1.0; P = 0.04) was 
      associated with low odds of an immunological response. The associations of HLA 
      genotype with HIV disease are different and sometimes even opposite in treated 
      and untreated patients.
FAU - Kuniholm, Mark H
AU  - Kuniholm MH
AD  - Department of Epidemiology & Population Health, Albert Einstein College of 
      Medicine, Belfer Building, Room 1308, 1300 Morris Park Ave., Bronx, NY 10461, 
      USA. mark.kuniholm@einstein.yu.edu
FAU - Gao, Xiaojiang
AU  - Gao X
FAU - Xue, Xiaonan
AU  - Xue X
FAU - Kovacs, Andrea
AU  - Kovacs A
FAU - Anastos, Kathryn
AU  - Anastos K
FAU - Marti, Darlene
AU  - Marti D
FAU - Greenblatt, Ruth M
AU  - Greenblatt RM
FAU - Cohen, Mardge H
AU  - Cohen MH
FAU - Minkoff, Howard
AU  - Minkoff H
FAU - Gange, Stephen J
AU  - Gange SJ
FAU - Fazzari, Melissa
AU  - Fazzari M
FAU - Young, Mary A
AU  - Young MA
FAU - Strickler, Howard D
AU  - Strickler HD
FAU - Carrington, Mary
AU  - Carrington M
LA  - eng
GR  - UO1-HD-32632/HD/NICHD NIH HHS/United States
GR  - UO1-AI-34989/AI/NIAID NIH HHS/United States
GR  - U01 AI031834/AI/NIAID NIH HHS/United States
GR  - R56 AI052065/AI/NIAID NIH HHS/United States
GR  - U01 AI035004/AI/NIAID NIH HHS/United States
GR  - 5P30AI051519-08/AI/NIAID NIH HHS/United States
GR  - P30 AI051519/AI/NIAID NIH HHS/United States
GR  - R01 AI057006/AI/NIAID NIH HHS/United States
GR  - U01-AI-35004/AI/NIAID NIH HHS/United States
GR  - UO1-AI-34993/AI/NIAID NIH HHS/United States
GR  - U01 AI034994/AI/NIAID NIH HHS/United States
GR  - ImNIH/Intramural NIH HHS/United States
GR  - P30 AI027763/AI/NIAID NIH HHS/United States
GR  - UO1-AI-42590/AI/NIAID NIH HHS/United States
GR  - UO1-AI-31834/AI/NIAID NIH HHS/United States
GR  - P30 AI060354/AI/NIAID NIH HHS/United States
GR  - HHSN261200800001E/CA/NCI NIH HHS/United States
GR  - UO1-AI-34994/AI/NIAID NIH HHS/United States
GR  - R01A1052065/PHS HHS/United States
GR  - UL1 RR024131/RR/NCRR NIH HHS/United States
GR  - U01 AI034989/AI/NIAID NIH HHS/United States
GR  - R01 AI052065/AI/NIAID NIH HHS/United States
GR  - 5R01AI057006/AI/NIAID NIH HHS/United States
GR  - HHSN261200800001C/RC/CCR NIH HHS/United States
GR  - U01 AI034993/AI/NIAID NIH HHS/United States
GR  - U01 HD032632/HD/NICHD NIH HHS/United States
GR  - U01 AI042590/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, N.I.H., Intramural
DEP - 20110817
PL  - United States
TA  - J Virol
JT  - Journal of virology
JID - 0113724
RN  - 0 (Anti-HIV Agents)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adult
MH  - Anti-HIV Agents/*administration & dosage
MH  - *Antiretroviral Therapy, Highly Active
MH  - CD4 Lymphocyte Count
MH  - Disease Progression
MH  - Female
MH  - Genotype
MH  - HIV Infections/*drug therapy/*genetics
MH  - HLA Antigens/*genetics
MH  - Humans
MH  - Viral Load
PMC - PMC3187522
EDAT- 2011/08/19 06:00
MHDA- 2011/11/08 06:00
PMCR- 2012/04/01
CRDT- 2011/08/19 06:00
PHST- 2011/08/19 06:00 [entrez]
PHST- 2011/08/19 06:00 [pubmed]
PHST- 2011/11/08 06:00 [medline]
PHST- 2012/04/01 00:00 [pmc-release]
AID - JVI.00804-11 [pii]
AID - 0804-11 [pii]
AID - 10.1128/JVI.00804-11 [doi]
PST - ppublish
SO  - J Virol. 2011 Oct;85(20):10826-33. doi: 10.1128/JVI.00804-11. Epub 2011 Aug 17.