PMID- 21852035
OWN - NLM
STAT- MEDLINE
DCOM- 20111108
LR  - 20131121
IS  - 1872-7980 (Electronic)
IS  - 0304-3835 (Linking)
VI  - 311
IP  - 2
DP  - 2011 Dec 8
TI  - Combined treatment with exogenous estradiol and progesterone increases the 
      incidence of breast cancer in TA2 mice without ovaries.
PG  - 171-6
LID - 10.1016/j.canlet.2011.07.011 [doi]
AB  - TA2 mice have a high incidence of spontaneous breast cancer without chemical 
      stimulus. There are two proposed explanations for this phenomenon: one is 
      gravidity and the frequency of pregnancies, and the other is related to the 
      presence of the mouse mammary tumor virus (MMTV). MMTV is hormonally regulated 
      and indirectly promotes tumor formation by leading to the activation of Wnt 
      oncogenes through insertional mutagenesis. In order to clarify the relationship 
      between estrogen, progesterone, MMTV, Wnt oncogenes and breast cancer, ovaries 
      from virgin female TA2 mice were removed and the mice were treated with exogenous 
      estradiol and progesterone in different patterns. This study found that the 
      combination of exogenous estradiol and progesterone induced breast cancer 
      formation in TA2 mice without ovaries. MMTV-LTR mRNA exhibited the highest 
      expression in tumor tissue from the combination treatment group (CT). Mammary 
      tissue from mice in the CT group had the highest Wnt1, Wnt5a, Wnt5b and Wnt10b 
      mRNA expression levels. These results indicate that estradiol and progesterone 
      act in a synergistic manner to upregulate MMTV, which subsequently induces breast 
      cancer in TA2 mice. Various members of the Wnt gene family may play specific 
      roles in different stages of carcinogenesis in TA2 mice.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Yin, Yu
AU  - Yin Y
AD  - Department of Pathology, Anhui Medical University, Hefei, Anhui Province, PR 
      China.
FAU - Yang, Zhengduo
AU  - Yang Z
FAU - Zhang, Shiwu
AU  - Zhang S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110730
PL  - Ireland
TA  - Cancer Lett
JT  - Cancer letters
JID - 7600053
RN  - 0 (Gonadal Steroid Hormones)
RN  - 0 (RNA, Messenger)
RN  - 0 (Wnt Proteins)
RN  - 4G7DS2Q64Y (Progesterone)
RN  - 4TI98Z838E (Estradiol)
SB  - IM
MH  - Animals
MH  - Cell Transformation, Viral/physiology
MH  - Estradiol/*metabolism/toxicity
MH  - Female
MH  - Gene Expression
MH  - Gene Expression Profiling
MH  - Gonadal Steroid Hormones/*metabolism/toxicity
MH  - Mammary Neoplasms, Experimental/chemically induced/*metabolism/virology
MH  - Mammary Tumor Virus, Mouse
MH  - Mice
MH  - Ovariectomy
MH  - Progesterone/*metabolism/toxicity
MH  - RNA, Messenger/analysis
MH  - Retroviridae Infections/*complications/metabolism
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Tumor Virus Infections/*complications/metabolism
MH  - Up-Regulation
MH  - Wnt Proteins/biosynthesis
EDAT- 2011/08/20 06:00
MHDA- 2011/11/09 06:00
CRDT- 2011/08/20 06:00
PHST- 2011/05/19 00:00 [received]
PHST- 2011/06/26 00:00 [revised]
PHST- 2011/07/10 00:00 [accepted]
PHST- 2011/08/20 06:00 [entrez]
PHST- 2011/08/20 06:00 [pubmed]
PHST- 2011/11/09 06:00 [medline]
AID - S0304-3835(11)00407-1 [pii]
AID - 10.1016/j.canlet.2011.07.011 [doi]
PST - ppublish
SO  - Cancer Lett. 2011 Dec 8;311(2):171-6. doi: 10.1016/j.canlet.2011.07.011. Epub 
      2011 Jul 30.