PMID- 21854404
OWN - NLM
STAT- MEDLINE
DCOM- 20120817
LR  - 20120423
IS  - 1365-2265 (Electronic)
IS  - 0300-0664 (Linking)
VI  - 76
IP  - 6
DP  - 2012 Jun
TI  - Glucose fluctuations in subjects with normal glucose tolerance, impaired glucose 
      regulation and newly diagnosed type 2 diabetes mellitus.
PG  - 810-5
LID - 10.1111/j.1365-2265.2011.04205.x [doi]
AB  - OBJECTIVE: Glycemic variability is poorly studied in the nondiabetic individuals 
      and newly diagnosed patients with type 2 diabetes. The aim of the study is to 
      investigate the characteristics of glucose fluctuations in subjects with normal 
      glucose tolerance (NGT), impaired glucose regulation (IGR) and newly diagnosed, 
      drug-naive type 2 diabetes mellitus (DM-2). DESIGN AND PATIENTS: This is a 
      cross-sectional study of three groups including 53 subjects with IGR, 56 DM-2 
      patients and 53 NGT individuals. Monitoring by a continuous glucose monitoring 
      system (CGMS((R)) System Gold()) was performed for three consecutive days. 
      MEASUREMENTS: Mean blood glucose (MBG), standard deviation of MBG (SDBG), largest 
      amplitude of glycemic excursions (LAGE) and mean amplitude of glycemic excursions 
      (MAGE) were calculated to estimate intraday blood glucose variability. Interday 
      variability of glucose was evaluated by absolute means of daily differences 
      (MODD). Postprandial glucose excursion (PPGE) was calculated to assess the 
      influence of meals on glucose fluctuation. RESULTS: Twenty-two percentage of NGT 
      and 33.9% of IGR individuals experienced blood glucose >/= 11.1 mmol/l; 49.1% of 
      NGT, 50.9% of IGR and 30.8% of DM-2 participants had hypoglycemic episodes (CGM 
      values <3.9 mmol/l). The IGR and DM-2 groups had greater SDBG (P = 0.010 and P < 
      0.001), LAGE (P = 0.014 and P < 0.001) and MAGE (P = 0.044 and P < 0.001) 
      compared with the NGT group. Significantly greater MODD and PPGEs were found in 
      the DM-2 groups than in the IGR and NGT groups (P < 0.001). The DM-2 patients had 
      higher 72-MBG and glucose levels overnight than the NGT and IGR subjects (P < 
      0.001). In the patients with diabetes, MAGE was positively associated with MODD 
      (r = 0.558, P < 0.001) and PPGEs (r = 0.738-0.843, P < 0.001). CONCLUSIONS: 
      Glucose variability is present to an increasing degree from NGT to IGR and IGR to 
      DM-2. Compared with the NGT individuals, the IGR and DM-2 subjects show more 
      predominant intraday glucose fluctuations. The DM-2 patients demonstrate 
      increased PPGEs, higher glucose levels overnight and greater interday 
      fluctuations.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - Wang, Chun
AU  - Wang C
AD  - Department of Endocrinology and Metabolism, West China Hospital, Sichuan 
      University, Sichuan, China.
FAU - Lv, Lifang
AU  - Lv L
FAU - Yang, Yanzhi
AU  - Yang Y
FAU - Chen, Dawei
AU  - Chen D
FAU - Liu, Guanjian
AU  - Liu G
FAU - Chen, Lihong
AU  - Chen L
FAU - Song, Yuanxia
AU  - Song Y
FAU - He, Liping
AU  - He L
FAU - Li, Xiujun
AU  - Li X
FAU - Tian, Haoming
AU  - Tian H
FAU - Jia, Weiping
AU  - Jia W
FAU - Ran, Xingwu
AU  - Ran X
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Clin Endocrinol (Oxf)
JT  - Clinical endocrinology
JID - 0346653
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Adult
MH  - Blood Glucose/analysis/*metabolism
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Female
MH  - Glucose Intolerance/*blood
MH  - Glucose Tolerance Test
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Postprandial Period/physiology
EDAT- 2011/08/23 06:00
MHDA- 2012/08/18 06:00
CRDT- 2011/08/23 06:00
PHST- 2011/08/23 06:00 [entrez]
PHST- 2011/08/23 06:00 [pubmed]
PHST- 2012/08/18 06:00 [medline]
AID - 10.1111/j.1365-2265.2011.04205.x [doi]
PST - ppublish
SO  - Clin Endocrinol (Oxf). 2012 Jun;76(6):810-5. doi: 
      10.1111/j.1365-2265.2011.04205.x.