PMID- 21855149
OWN - NLM
STAT- MEDLINE
DCOM- 20111220
LR  - 20211020
IS  - 1872-9142 (Electronic)
IS  - 0161-5890 (Print)
IS  - 0161-5890 (Linking)
VI  - 49
IP  - 1-2
DP  - 2011 Oct
TI  - Increased expression of beta-arrestin 1 and 2 in murine models of rheumatoid 
      arthritis: isoform specific regulation of inflammation.
PG  - 64-74
LID - 10.1016/j.molimm.2011.07.021 [doi]
AB  - Pro-inflammatory cytokines and chemokines play critical roles in autoimmune 
      diseases including rheumatoid arthritis (RA). Recently, it has been reported that 
      beta-arrestin 1 and 2 are involved in the regulation of inflammation. We 
      hypothesized that beta-arrestin 1 and 2 play critical roles in murine models of RA. 
      Using a collagen-induced arthritis (CIA) and a human TNFalpha transgenic (TNFtg) 
      mouse model, we demonstrated that beta-arrestin 1 and 2 expression are significantly 
      increased in joint tissue of CIA mice and TNFtg mice. In fibroblast-like 
      synoviocytes (FLS) isolated from hind knee joint of CIA mice, we observed an 
      increase of beta-arrestin 1 and 2 protein and mRNA levels in the early stage of 
      arthritis. In FLS, low molecular weight hyaluronan (HA)-induced TNFalpha and IL-6 
      production was increased by overexpression of beta-arrestin 1 but decreased by 
      overexpression of beta-arrestin 2 demonstrating isoform specific regulation. TNFalpha 
      and HA induced an increase of beta-arrestin 1 and 2 expression in FLS, while high 
      mobility group box (HMGB)-1 only stimulated beta-arrestin 1 expression. TNFalpha- or 
      HA-induced beta-arrestin 2 expression was blocked by a p38 inhibitor. To examine the 
      in vivo role of beta-arrestin 2 in the pathogenesis of arthritis, WT and beta-arrestin 
      2 KO mice were subjected to collagen antibody-induced arthritis (CAIA). 
      beta-Arrestin 2 KO mice exhibited more severe arthritis in CAIA. Thus beta-arrestin 2 
      is anti-inflammatory in CAIA. These composite observations suggest that 
      beta-arrestin 1 and 2 differentially regulate FLS inflammation and increased 
      beta-arrestin 2 may reduce experimental arthritis severity.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Li, Pengfei
AU  - Li P
AD  - Department of Neurosciences, Medical University of South Carolina, Charleston, SC 
      29425, United States. lippe@musc.edu
FAU - Cook, James A
AU  - Cook JA
FAU - Gilkeson, Gary S
AU  - Gilkeson GS
FAU - Luttrell, Louis M
AU  - Luttrell LM
FAU - Wang, Liping
AU  - Wang L
FAU - Borg, Keith T
AU  - Borg KT
FAU - Halushka, Perry V
AU  - Halushka PV
FAU - Fan, Hongkuan
AU  - Fan H
LA  - eng
GR  - R01 GM027673-30/GM/NIGMS NIH HHS/United States
GR  - R01 GM027673/GM/NIGMS NIH HHS/United States
GR  - AI079248/AI/NIAID NIH HHS/United States
GR  - GM27673/GM/NIGMS NIH HHS/United States
GR  - R03 AI079248-02/AI/NIAID NIH HHS/United States
GR  - R03 AI079248/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20110819
PL  - England
TA  - Mol Immunol
JT  - Molecular immunology
JID - 7905289
RN  - 0 (ARRB1 protein, human)
RN  - 0 (ARRB2 protein, human)
RN  - 0 (Arrb1 protein, mouse)
RN  - 0 (Arrb2 protein, mouse)
RN  - 0 (Arrestins)
RN  - 0 (Protein Isoforms)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (beta-Arrestin 1)
RN  - 0 (beta-Arrestin 2)
RN  - 0 (beta-Arrestins)
SB  - IM
MH  - Animals
MH  - Arrestins/*biosynthesis/immunology
MH  - Arthritis, Experimental/immunology/*metabolism
MH  - Arthritis, Rheumatoid/immunology/*metabolism
MH  - Blotting, Western
MH  - Disease Models, Animal
MH  - Fibroblasts/immunology/metabolism
MH  - Humans
MH  - Inflammation/immunology/metabolism
MH  - Mice
MH  - Mice, Inbred DBA
MH  - Mice, Knockout
MH  - Mice, Transgenic
MH  - Protein Isoforms/immunology/metabolism
MH  - Real-Time Polymerase Chain Reaction
MH  - Tumor Necrosis Factor-alpha/genetics/immunology
MH  - beta-Arrestin 1
MH  - beta-Arrestin 2
MH  - beta-Arrestins
PMC - PMC3205331
MID - NIHMS319600
EDAT- 2011/08/23 06:00
MHDA- 2011/12/21 06:00
PMCR- 2012/10/01
CRDT- 2011/08/23 06:00
PHST- 2011/06/28 00:00 [received]
PHST- 2011/07/26 00:00 [revised]
PHST- 2011/07/27 00:00 [accepted]
PHST- 2011/08/23 06:00 [entrez]
PHST- 2011/08/23 06:00 [pubmed]
PHST- 2011/12/21 06:00 [medline]
PHST- 2012/10/01 00:00 [pmc-release]
AID - S0161-5890(11)00689-4 [pii]
AID - 10.1016/j.molimm.2011.07.021 [doi]
PST - ppublish
SO  - Mol Immunol. 2011 Oct;49(1-2):64-74. doi: 10.1016/j.molimm.2011.07.021. Epub 2011 
      Aug 19.