PMID- 21855175
OWN - NLM
STAT- MEDLINE
DCOM- 20120615
LR  - 20211020
IS  - 1558-1497 (Electronic)
IS  - 0197-4580 (Print)
IS  - 0197-4580 (Linking)
VI  - 33
IP  - 4
DP  - 2012 Apr
TI  - 3xTgAD mice exhibit altered behavior and elevated Abeta after chronic mild social 
      stress.
PG  - 830.e1-12
LID - 10.1016/j.neurobiolaging.2011.07.005 [doi]
AB  - Chronic stress may be a risk factor for developing Alzheimer's disease (AD), but 
      most studies of the effects of stress in models of AD utilize acute adverse 
      stressors of questionable clinical relevance. The goal of this work was to 
      determine how chronic psychosocial stress affects behavioral and pathological 
      outcomes in an animal model of AD, and to elucidate underlying mechanisms. A 
      triple-transgenic mouse model of AD (3xTgAD mice) and nontransgenic control mice 
      were used to test for an affect of chronic mild social stress on blood glucose, 
      plasma glucocorticoids, plasma insulin, anxiety, and hippocampal amyloid 
      beta-particle (Abeta), phosphorylated tau (ptau), and brain-derived neurotrophic factor 
      (BDNF) levels. Despite the fact that both control and 3xTgAD mice experienced 
      rises in corticosterone during episodes of mild social stress, at the end of the 
      6-week stress period 3xTgAD mice displayed increased anxiety, elevated levels of 
      Abeta oligomers and intraneuronal Abeta, and decreased brain-derived neurotrophic 
      factor levels, whereas control mice did not. Findings suggest 3xTgAD mice are 
      more vulnerable than control mice to chronic psychosocial stress, and that such 
      chronic stress exacerbates Abeta accumulation and impairs neurotrophic signaling.
CI  - Published by Elsevier Inc.
FAU - Rothman, Sarah M
AU  - Rothman SM
AD  - Laboratory of Neurosciences, National Institute on Aging, Intramural Research 
      Program, National Institutes of Health, Baltimore, MD 21224, USA.
FAU - Herdener, Nathan
AU  - Herdener N
FAU - Camandola, Simonetta
AU  - Camandola S
FAU - Texel, Sarah J
AU  - Texel SJ
FAU - Mughal, Mohamed R
AU  - Mughal MR
FAU - Cong, Wei-Na
AU  - Cong WN
FAU - Martin, Bronwen
AU  - Martin B
FAU - Mattson, Mark P
AU  - Mattson MP
LA  - eng
GR  - Z01 AG000332-01/ImNIH/Intramural NIH HHS/United States
GR  - Z01 AG000331-01/ImNIH/Intramural NIH HHS/United States
GR  - T32 EY017203/EY/NEI NIH HHS/United States
GR  - Z01 AG000312-07/ImNIH/Intramural NIH HHS/United States
GR  - Z01 AG000330-01/ImNIH/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
DEP - 20110819
PL  - United States
TA  - Neurobiol Aging
JT  - Neurobiology of aging
JID - 8100437
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Amyloid beta-Protein Precursor)
RN  - 0 (Blood Glucose)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Glucocorticoids)
RN  - 0 (Insulin)
RN  - 0 (PSEN1 protein, human)
RN  - 0 (Presenilin-1)
RN  - 0 (tau Proteins)
SB  - IM
MH  - Alzheimer Disease/blood/*complications/genetics/pathology
MH  - Amyloid beta-Peptides/*metabolism
MH  - Amyloid beta-Protein Precursor/genetics
MH  - Analysis of Variance
MH  - Animals
MH  - Anxiety/*etiology
MH  - Behavior, Animal/*physiology
MH  - Blood Glucose/metabolism
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Disease Models, Animal
MH  - Fasting
MH  - Glucocorticoids/blood
MH  - Hippocampus/pathology
MH  - Humans
MH  - Insulin/blood
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Transgenic
MH  - Mutation/genetics
MH  - Presenilin-1/genetics
MH  - *Social Behavior
MH  - Stress, Psychological/*physiopathology
MH  - Time Factors
MH  - tau Proteins/genetics/metabolism
PMC - PMC4074356
MID - NIHMS591346
COIS- Disclosure Statement The authors report no conflicts of interest.
EDAT- 2011/08/23 06:00
MHDA- 2012/06/16 06:00
PMCR- 2014/06/28
CRDT- 2011/08/23 06:00
PHST- 2011/04/06 00:00 [received]
PHST- 2011/06/30 00:00 [revised]
PHST- 2011/07/08 00:00 [accepted]
PHST- 2011/08/23 06:00 [entrez]
PHST- 2011/08/23 06:00 [pubmed]
PHST- 2012/06/16 06:00 [medline]
PHST- 2014/06/28 00:00 [pmc-release]
AID - S0197-4580(11)00272-7 [pii]
AID - 10.1016/j.neurobiolaging.2011.07.005 [doi]
PST - ppublish
SO  - Neurobiol Aging. 2012 Apr;33(4):830.e1-12. doi: 
      10.1016/j.neurobiolaging.2011.07.005. Epub 2011 Aug 19.