PMID- 21856019
OWN - NLM
STAT- MEDLINE
DCOM- 20111230
LR  - 20171116
IS  - 1872-7603 (Electronic)
IS  - 0165-0378 (Linking)
VI  - 91
IP  - 1-2
DP  - 2011 Sep
TI  - Immunosuppressive effect of progesterone on dendritic cells in mice.
PG  - 17-23
LID - 10.1016/j.jri.2011.06.101 [doi]
AB  - Progesterone has been demonstrated to be involved in maintaining pregnancy by 
      regulating immunocytes. Dendritic cells (DCs), the most potent triggers of the 
      adaptive immune response, express receptors for steroid hormones and are regarded 
      as one of the primary targets of progesterone. However, the functional 
      modification of DCs by progesterone remains poorly understood. Here, we report 
      that progesterone does not affect the morphology or apoptosis of murine bone 
      marrow-derived DCs. Progesterone-treated DCs were characterized by decreased 
      expression of Ia (MHC class II), CD80 and CD86, increased production of IL-10, 
      and decreased secretion of IL-12. Compared with mature DCs (mDCs), activated 
      progesterone-treated DCs had a reduced capacity to stimulate CD4(+) T cell 
      proliferation. The observation that progesterone-treated DCs could attenuate 
      delayed-type hypersensitivity (DTH) responses in vivo suggests that progesterone 
      mediates suppressive DC activity. However, transfer of progesterone-treated DCs 
      into the peritoneal cavity of mice did not elevate the percentage of 
      CD4(+)CD25(+)Foxp3(+) regulatory T cells in the spleen. Overall, our study helps 
      to increase understanding of the role of DCs exposed to progesterone in the 
      maintenance of pregnancy.
CI  - Copyright (c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Xu, Yingping
AU  - Xu Y
AD  - Department of Immunology, Taishan Medical University, Taian 271016, Shandong 
      Province, People's Republic of China.
FAU - He, Hao
AU  - He H
FAU - Li, Chuanwei
AU  - Li C
FAU - Shi, Yunzhi
AU  - Shi Y
FAU - Wang, Qian
AU  - Wang Q
FAU - Li, Wei
AU  - Li W
FAU - Song, Wengang
AU  - Song W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - J Reprod Immunol
JT  - Journal of reproductive immunology
JID - 8001906
RN  - 0 (B7-1 Antigen)
RN  - 0 (B7-2 Antigen)
RN  - 0 (Cd86 protein, mouse)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (IL10 protein, mouse)
RN  - 0 (Immunosuppressive Agents)
RN  - 0 (Progestins)
RN  - 130068-27-8 (Interleukin-10)
RN  - 187348-17-0 (Interleukin-12)
RN  - 4G7DS2Q64Y (Progesterone)
SB  - IM
MH  - Adaptive Immunity/immunology/physiology
MH  - Animals
MH  - Apoptosis/drug effects/immunology
MH  - B7-1 Antigen/immunology
MH  - B7-2 Antigen/immunology
MH  - Cell Proliferation/drug effects
MH  - Dendritic Cells/cytology/*immunology
MH  - Female
MH  - Gene Expression Regulation/drug effects/physiology
MH  - Histocompatibility Antigens Class II/immunology
MH  - Immune Tolerance/*physiology
MH  - Immunosuppressive Agents/*immunology/pharmacology
MH  - Interleukin-10/immunology
MH  - Interleukin-12/immunology
MH  - Mice
MH  - Mice, Transgenic
MH  - Pregnancy/*immunology
MH  - Progesterone/*immunology/pharmacology
MH  - Progestins/immunology/pharmacology
MH  - T-Lymphocytes, Regulatory/cytology/immunology
EDAT- 2011/08/23 06:00
MHDA- 2011/12/31 06:00
CRDT- 2011/08/23 06:00
PHST- 2011/01/27 00:00 [received]
PHST- 2011/06/06 00:00 [revised]
PHST- 2011/06/21 00:00 [accepted]
PHST- 2011/08/23 06:00 [entrez]
PHST- 2011/08/23 06:00 [pubmed]
PHST- 2011/12/31 06:00 [medline]
AID - S0165-0378(11)00273-7 [pii]
AID - 10.1016/j.jri.2011.06.101 [doi]
PST - ppublish
SO  - J Reprod Immunol. 2011 Sep;91(1-2):17-23. doi: 10.1016/j.jri.2011.06.101.