PMID- 21856092
OWN - NLM
STAT- MEDLINE
DCOM- 20120209
LR  - 20111017
IS  - 1618-0631 (Electronic)
IS  - 0344-0338 (Linking)
VI  - 207
IP  - 9
DP  - 2011 Sep 15
TI  - Effects of diphenyl diselenide on oxidative stress induced by sepsis in rats.
PG  - 554-8
LID - 10.1016/j.prp.2011.06.005 [doi]
AB  - Sepsis is a potentially deadly complication that can be caused by different 
      factors. Actually, it is known that oxidative stress is involved in the 
      pathogenesis of sepsis. Thus, the aim of this study was to evaluate the effect of 
      diphenyl diselenide (PhSe)(2), an emergent compound, on oxidative stress 
      parameters induced by sepsis in rats. Animals were pre-injected with (PhSe)(2) or 
      vehicle. Twenty-four hours later, sepsis was induced by cecal ligation puncture 
      (CLP). After 12 h, liver was taken for thiobarbituric acid reactive species 
      (TBARS) measurement, delta-aminolevunic acid dehydratase (delta-ALA-D), Cu/Zn superoxide 
      dismutase (Cu/Zn SOD) and catalase (CAT) activities assay. The sepsis increased 
      TBARS, inhibited delta-ALA-D, activated Cu/Zn SOD and had a tendency to decrease CAT 
      activity. However, (PhSe)(2) prevented the TBARS formation, but did not prevent 
      the inhibition of delta-ALA-D activity in the animals with damage. Thus, this study 
      showed that (PhSe)(2) partially prevents the oxidative stress induced by sepsis, 
      indicating the potential of this compound as a treatment for this pathology. 
      Nevertheless, more tests should be performed to confirm the hypothesis suggested 
      here.
CI  - Copyright (c) 2011 Elsevier GmbH. All rights reserved.
FAU - Prauchner, Carlos A
AU  - Prauchner CA
AD  - Departamento de Quimica, Centro de Ciencias Naturais e Exatas, Universidade 
      Federal de Santa Maria, Santa Maria, RS, Brazil.
FAU - Prestes, Alessandro de S
AU  - Prestes Ade S
FAU - da Rocha, Joao B T
AU  - da Rocha JB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Pathol Res Pract
JT  - Pathology, research and practice
JID - 7806109
RN  - 0 (Antioxidants)
RN  - 0 (Benzene Derivatives)
RN  - 0 (Organoselenium Compounds)
RN  - 0 (Thiobarbituric Acid Reactive Substances)
RN  - 1666-13-3 (diphenyldiselenide)
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - EC 4.2.1.24 (Porphobilinogen Synthase)
SB  - IM
MH  - Animals
MH  - Antioxidants/*pharmacology
MH  - Benzene Derivatives/*pharmacology
MH  - Catalase/metabolism
MH  - Cecum/injuries
MH  - Disease Models, Animal
MH  - Ligation
MH  - Liver/drug effects/metabolism
MH  - Male
MH  - Organoselenium Compounds/*pharmacology
MH  - Oxidative Stress/*drug effects
MH  - Porphobilinogen Synthase/metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Sepsis/*drug therapy/metabolism/pathology
MH  - Superoxide Dismutase/metabolism
MH  - Thiobarbituric Acid Reactive Substances/metabolism
EDAT- 2011/08/23 06:00
MHDA- 2012/02/10 06:00
CRDT- 2011/08/23 06:00
PHST- 2010/07/12 00:00 [received]
PHST- 2011/06/02 00:00 [revised]
PHST- 2011/06/08 00:00 [accepted]
PHST- 2011/08/23 06:00 [entrez]
PHST- 2011/08/23 06:00 [pubmed]
PHST- 2012/02/10 06:00 [medline]
AID - S0344-0338(11)00144-0 [pii]
AID - 10.1016/j.prp.2011.06.005 [doi]
PST - ppublish
SO  - Pathol Res Pract. 2011 Sep 15;207(9):554-8. doi: 10.1016/j.prp.2011.06.005.