PMID- 21857593
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20110822
IS  - 1319-6138 (Print)
IS  - 1319-6138 (Linking)
VI  - 12
IP  - 2
DP  - 2007 Apr
TI  - Human leukocyte antigen typing in Iraqi multiple sclerosis patients.
PG  - 127-32
AB  - OBJECTIVE: To assess the relative frequency of human leukocyte antigen (HLA) 
      class I and class II in Iraqi multiple sclerosis (MS) patients, and to ascertain 
      whether they offer any etiologic or protective role. METHODS: We conducted this 
      study in the Baghdad MS Clinic and Teaching Laboratory Institute, Medical City, 
      Baghdad Teaching Hospital, Baghdad, Iraq from March to July 2004. We enrolled 44 
      randomly selected MS patients and 69 healthy unrelated age- and sex-matched 
      controls. We carried out HLA class I and class II typing on both groups using the 
      microlymphocytotoxicity test. RESULTS: The HLA class I typing revealed no 
      consistent association between MS and HLA-A and -Cw, while HLA-B5 and -B44 were 
      found to possibly be risk factors for MS with odds ratio (OR) of 10.2 for -B5 and 
      4.4 for -B44. The HLA-B35 may form a protective factor with OR of 0.1. The HLA 
      class II typing revealed an etiologic risk for HLA-DR4 (OR=10.3) and a protective 
      effect for HLA-DR2 (OR=0.3) and -DR7 (OR=0.2), and etiologic effect for -DQ1 
      (OR=3.3) and -DQ3 (OR=3). CONCLUSION: The HLA DR4 carries the strongest 
      association with MS in Iraqi patients. This study adds to the well-known 
      diversity of HLA-allelic association of MS in different populations, and 
      emphasizes the complexity of genetic susceptibility to MS.
FAU - Saleem, Maysoon A
AU  - Saleem MA
AD  - The Teaching Laboratory Institute, Medical City, Baghdad Teaching Hospital, 
      Baghdad, Iraq.
FAU - Mukhelif, Hamid F
AU  - Mukhelif HF
FAU - Moussawi, Khalida M
AU  - Moussawi KM
FAU - Al-Khafaji, Jasim T
AU  - Al-Khafaji JT
LA  - eng
PT  - Journal Article
PL  - Saudi Arabia
TA  - Neurosciences (Riyadh)
JT  - Neurosciences (Riyadh, Saudi Arabia)
JID - 101252453
EDAT- 2007/04/01 00:00
MHDA- 2007/04/01 00:01
CRDT- 2011/08/23 06:00
PHST- 2011/08/23 06:00 [entrez]
PHST- 2007/04/01 00:00 [pubmed]
PHST- 2007/04/01 00:01 [medline]
PST - ppublish
SO  - Neurosciences (Riyadh). 2007 Apr;12(2):127-32.