PMID- 21858389
OWN - NLM
STAT- MEDLINE
DCOM- 20120125
LR  - 20110822
IS  - 1658-3175 (Electronic)
IS  - 0379-5284 (Linking)
VI  - 32
IP  - 8
DP  - 2011 Aug
TI  - In-hospital adverse clinical outcomes of ST elevation myocardial infarction 
      patients with renal dysfunction. Insights from the Saudi Project for Assessment 
      of Coronary Events.
PG  - 806-12
AB  - OBJECTIVE: To explore the prognostic value of baseline estimated glomerular 
      filtration rate (eGFR) in Saudi patients presenting with ST elevation myocardial 
      infarction (STEMI), and its impact on hospital therapies. METHODS: The STEMI 
      patients with a baseline serum Creatinine enrolled in the SPACE (Saudi Project 
      for Assessment of Coronary Events) registry were analyzed. This study was 
      performed in several regions in Saudi Arabia between December 2005 to December 
      2007. Based on eGFR levels, patients were classified into: more than 90.1 ml/min 
      (normal renal function), 90-60.1 (borderline/mildly impaired renal function), 
      60-30 (moderate renal dysfunction), and less than 30 ml/min/1.73 m2 (severe renal 
      dysfunction). RESULTS: Two thousand and fifty-eight patients qualified for this 
      study. Of these, 1058 patients had renal dysfunction. Patients with renal 
      dysfunction were older, and had a higher prevalence of risk factors for 
      atherosclerosis. Patients with moderate or severe renal dysfunction were less 
      likely to be treated with beta blockers, angiotensin converting enzymes 
      inhibitors, statins, or reperfusion therapies. Significantly worse outcomes were 
      seen with lower eGFR in a stepwise fashion. The adjusted odds ratio of 
      in-hospital death in patients with eGFR less than 30 ml/min was 5.3 (95% CI, 
      1.15-25.51, p=0.0383). CONCLUSION: A low baseline eGFR in STEMI patients is an 
      independent predictor of all major adverse cardiovascular outcomes, and a marker 
      for less aggressive in-hospital therapy.
FAU - Al Faleh, Hussam F
AU  - Al Faleh HF
AD  - Department of Cardiac Sciences, College of Medicine, King Khalid University 
      Hospital, King Saud University, Riyadh, Kingdom of Saudi Arabia. 
      halfaleh@hotmail.com
FAU - AlSuwaida, Abdulkareem O
AU  - AlSuwaida AO
FAU - Hersi, Ahmad S
AU  - Hersi AS
FAU - Ullah, Anhar
AU  - Ullah A
FAU - AlShahrani, Ali M
AU  - AlShahrani AM
FAU - Al-Nemer, Khalid A
AU  - Al-Nemer KA
FAU - Al-Saif, Shukri M
AU  - Al-Saif SM
FAU - Taraben, Amir M
AU  - Taraben AM
FAU - Kashour, Tarek S
AU  - Kashour TS
FAU - Ahmed, Waqar H
AU  - Ahmed WH
FAU - Balghith, Mohammed A
AU  - Balghith MA
FAU - Al-Habib, Khalid F
AU  - Al-Habib KF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Saudi Arabia
TA  - Saudi Med J
JT  - Saudi medical journal
JID - 7909441
SB  - IM
MH  - Adult
MH  - Aged
MH  - Electrocardiography
MH  - Female
MH  - *Glomerular Filtration Rate
MH  - Hospital Mortality
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*complications/mortality
MH  - Prognosis
MH  - Renal Insufficiency, Chronic/*complications
MH  - Saudi Arabia/epidemiology
EDAT- 2011/08/23 06:00
MHDA- 2012/01/26 06:00
CRDT- 2011/08/23 06:00
PHST- 2011/08/23 06:00 [entrez]
PHST- 2011/08/23 06:00 [pubmed]
PHST- 2012/01/26 06:00 [medline]
AID - 0' [pii]
PST - ppublish
SO  - Saudi Med J. 2011 Aug;32(8):806-12.