PMID- 21859459
OWN - NLM
STAT- MEDLINE
DCOM- 20120126
LR  - 20211020
IS  - 1476-511X (Electronic)
IS  - 1476-511X (Linking)
VI  - 10
DP  - 2011 Aug 22
TI  - Response by sex to statin plus ezetimibe or statin monotherapy: a pooled analysis 
      of 22,231 hyperlipidemic patients.
PG  - 146
LID - 10.1186/1476-511X-10-146 [doi]
AB  - BACKGROUND: Despite documented benefits of lipid-lowering treatment in women, a 
      considerable number are undertreated, and fewer achieve treatment targets vs. 
      men. METHODS: Data were combined from 27 double-blind, active or 
      placebo-controlled studies that randomized adult hypercholesterolemic patients to 
      statin or statin+ezetimibe. Consistency of treatment effect among men (n = 
      11,295) and women (n = 10,499) was assessed and percent of men and women was 
      calculated to evaluate the between-treatment ability to achieve specified 
      treatment levels between sexes. RESULTS: Baseline lipids and hs-CRP were 
      generally higher in women vs. men. Between-treatment differences were significant 
      for both sexes (all p < 0.001 except apolipoprotein A-I in men = 0.0389). Men 
      treated with ezetimibe+statin experienced significantly greater changes in LDL-C 
      (p = 0.0066), non-HDL-C, total cholesterol, triglycerides, HDL-C, apolipoprotein 
      A-I (all p < 0.0001) and apolipoprotein B (p = 0.0055) compared with women 
      treated with ezetimibe+statin. The odds of achieving LDL-C < 100 mg/dL, 
      apolipoprotein B < 90 mg/dL and the dual target [LDL-C < 100 mg/dL & apoliprotein 
      B < 90 mg/dL] was significantly greater for women vs. men and the odds of 
      achieving hs-CRP < 1 and < 2 mg/L and dual specified levels of [LDL-C < 100 mg/dL 
      and hs-CRP < 2 mg/L] were significantly greater for men vs. women. Women reported 
      significantly more gall-bladder-related, gastrointestinal-related, and allergic 
      reaction or rash-related adverse events (AEs) vs. men (no differences between 
      treatments). Men reported significantly more CK elevations (no differences 
      between treatments) and hepatitis-related AEs vs. women (significantly more with 
      ezetimibe+simvastatin vs. statin). CONCLUSIONS: These results suggest that small 
      sex-related differences may exist in response to lipid-lowering treatment and 
      achievement of specified lipid and hs-CRP levels, which may have implications 
      when managing hypercholesterolemia in women.
FAU - Abramson, Beth L
AU  - Abramson BL
AD  - St. Michael's Hospital, Toronto, Ontario, Canada. abramsonb@smh.ca
FAU - Benlian, Pascale
AU  - Benlian P
FAU - Hanson, Mary E
AU  - Hanson ME
FAU - Lin, Jianxin
AU  - Lin J
FAU - Shah, Arvind
AU  - Shah A
FAU - Tershakovec, Andrew M
AU  - Tershakovec AM
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20110822
PL  - England
TA  - Lipids Health Dis
JT  - Lipids in health and disease
JID - 101147696
RN  - 0 (Anticholesteremic Agents)
RN  - 0 (Azetidines)
RN  - 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors)
RN  - 0 (Lipids)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - EOR26LQQ24 (Ezetimibe)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Anticholesteremic Agents/administration & dosage/adverse effects/*therapeutic use
MH  - Azetidines/administration & dosage/adverse effects/*therapeutic use
MH  - C-Reactive Protein/analysis
MH  - Double-Blind Method
MH  - Drug Therapy, Combination/adverse effects
MH  - Ezetimibe
MH  - Female
MH  - Humans
MH  - Hydroxymethylglutaryl-CoA Reductase Inhibitors/administration & dosage/adverse 
      effects/*therapeutic use
MH  - Hyperlipidemias/blood/*drug therapy
MH  - Lipids/blood
MH  - Male
MH  - Middle Aged
MH  - Randomized Controlled Trials as Topic
MH  - Sex Factors
PMC - PMC3180404
EDAT- 2011/08/24 06:00
MHDA- 2012/01/27 06:00
PMCR- 2011/08/22
CRDT- 2011/08/24 06:00
PHST- 2011/07/28 00:00 [received]
PHST- 2011/08/22 00:00 [accepted]
PHST- 2011/08/24 06:00 [entrez]
PHST- 2011/08/24 06:00 [pubmed]
PHST- 2012/01/27 06:00 [medline]
PHST- 2011/08/22 00:00 [pmc-release]
AID - 1476-511X-10-146 [pii]
AID - 10.1186/1476-511X-10-146 [doi]
PST - epublish
SO  - Lipids Health Dis. 2011 Aug 22;10:146. doi: 10.1186/1476-511X-10-146.