PMID- 21859809
OWN - NLM
STAT- MEDLINE
DCOM- 20120119
LR  - 20110928
IS  - 1745-7270 (Electronic)
IS  - 1672-9145 (Linking)
VI  - 43
IP  - 10
DP  - 2011 Oct
TI  - Monocyte chemoattractant protein-1 induces endothelial cell apoptosis in vitro 
      through a p53-dependent mitochondrial pathway.
PG  - 787-95
LID - 10.1093/abbs/gmr072 [doi]
AB  - The cystine-cystine (CC) chemokine monocyte chemoattractant protein-1 (MCP-1) has 
      been established playing a pathogenic role in the development of atherosclerosis 
      due to its chemotactic ability of leading monocytes to locate to subendothelia. 
      Recent studies have revealed more MCP-1 functions other than chemotaxis. Here we 
      reported that various concentrations (0.1-100 ng/ml) of MCP-1 induced human 
      umbilical vein endothelial cell (HUVEC) strain CRL-1730 apoptosis, caspase-9 
      activation, and a couple of mitochondrial alterations. Moreover, MCP-1 
      upregulated p53 expression of HUVECs and the p53-specific inhibitor pifithrin-alpha 
      (PFTalpha) rescued the MCP-1-induced apoptosis of HUVECs. Furthermore, PKC (protein 
      kinase C) activation or inhibition might also affect HUVECs apoptosis induced by 
      MCP-1. These findings together demonstrate that MCP-1 exerts direct proapoptotic 
      effects on HUVECs in vitro via a p53-dependent mitochondrial pathway.
FAU - Zhang, Xuan
AU  - Zhang X
AD  - Department of Biochemistry, Zunyi Medical College, China.
FAU - Liu, Xiping
AU  - Liu X
FAU - Shang, Huifeng
AU  - Shang H
FAU - Xu, Yan
AU  - Xu Y
FAU - Qian, Minzhang
AU  - Qian M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110822
PL  - China
TA  - Acta Biochim Biophys Sin (Shanghai)
JT  - Acta biochimica et biophysica Sinica
JID - 101206716
RN  - 0 (Chemokine CCL2)
RN  - 0 (Tumor Suppressor Protein p53)
SB  - IM
MH  - *Apoptosis
MH  - Atherosclerosis/metabolism/pathology
MH  - Cells, Cultured
MH  - Chemokine CCL2/*metabolism
MH  - Endothelium, Vascular/*cytology/metabolism
MH  - Gene Expression Regulation
MH  - Humans
MH  - Mitochondria/*metabolism
MH  - Signal Transduction
MH  - Tumor Suppressor Protein p53/metabolism
MH  - Umbilical Veins/cytology
MH  - Up-Regulation
EDAT- 2011/08/24 06:00
MHDA- 2012/01/20 06:00
CRDT- 2011/08/24 06:00
PHST- 2011/08/24 06:00 [entrez]
PHST- 2011/08/24 06:00 [pubmed]
PHST- 2012/01/20 06:00 [medline]
AID - gmr072 [pii]
AID - 10.1093/abbs/gmr072 [doi]
PST - ppublish
SO  - Acta Biochim Biophys Sin (Shanghai). 2011 Oct;43(10):787-95. doi: 
      10.1093/abbs/gmr072. Epub 2011 Aug 22.