PMID- 21860753
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 2005-7563 (Electronic)
IS  - 2005-6419 (Print)
IS  - 2005-6419 (Linking)
VI  - 61
IP  - 1
DP  - 2011 Jul
TI  - Remifentanil alleviates transient cerebral ischemia-induced memory impairment 
      through suppression of apoptotic neuronal cell death in gerbils.
PG  - 63-8
LID - 10.4097/kjae.2011.61.1.63 [doi]
AB  - BACKGROUND: During neurosurgical procedures, patients are often exposed to 
      hypoxic and ischemic brain damage. Cerebral ischemia leads to neuronal cell death 
      and eventually causes neurological impairments. Remifentanil is a new ultra-short 
      acting phenylpiperidine opioid analgesic. In this study, we evaluated 
      remifentanil to determine if it exerts an anti-apoptotic effect in the 
      hippocampal dentate gyrus following transient global ischemia in gerbils. 
      METHODS: Step-down avoidance task, terminal deoxynucleotidyl transferase-mediated 
      dUTP nick end labeling (TUNEL) assay, and immunohistochemical staining for 
      caspase-3 were performed. RESULTS: The numbers of TUNEL-positive cells and 
      caspase-3-positive cells in the dentate gyrus were increased by ransient global 
      ischemia. Latency in the step-down avoidance task was increased by transient 
      global ischemia. Results revealed that apoptotic cell death in the dentate gyrus 
      was increased significantly following transient global ischemia, resulting in 
      memory impairment. However, treatment with remifentanil suppressed 
      ischemia-induced apoptosis in the dentate gyrus, thereby alleviating the memory 
      impairment that was induced by ischemic cerebral injury. CONCLUSIONS: These 
      results indicate that remifentanil may exert a neuroprotective effect on ischemic 
      brain damage during surgery.
FAU - Park, Sung-Wook
AU  - Park SW
AD  - Department of Anesthesiology and Pain Medicine, College of Medicine, Kyung Hee 
      University, Seoul, Korea.
FAU - Yi, Jae-Woo
AU  - Yi JW
FAU - Kim, Young-Min
AU  - Kim YM
FAU - Kang, Jong-Man
AU  - Kang JM
FAU - Kim, Dong Ok
AU  - Kim DO
FAU - Shin, Mal-Soon
AU  - Shin MS
FAU - Kim, Chang-Ju
AU  - Kim CJ
FAU - Lee, Doo Ik
AU  - Lee DI
FAU - Kim, Dong-Hee
AU  - Kim DH
FAU - Lee, Bong Jae
AU  - Lee BJ
LA  - eng
PT  - Journal Article
DEP - 20110717
PL  - Korea (South)
TA  - Korean J Anesthesiol
JT  - Korean journal of anesthesiology
JID - 101502451
PMC - PMC3155139
OTO - NOTNLM
OT  - Apoptosis
OT  - Memory deficit
OT  - Remifenanil
OT  - Transient cerebral ischemia
EDAT- 2011/08/24 06:00
MHDA- 2011/08/24 06:01
PMCR- 2011/07/01
CRDT- 2011/08/24 06:00
PHST- 2010/08/20 00:00 [received]
PHST- 2011/01/10 00:00 [revised]
PHST- 2011/01/20 00:00 [accepted]
PHST- 2011/08/24 06:00 [entrez]
PHST- 2011/08/24 06:00 [pubmed]
PHST- 2011/08/24 06:01 [medline]
PHST- 2011/07/01 00:00 [pmc-release]
AID - 10.4097/kjae.2011.61.1.63 [doi]
PST - ppublish
SO  - Korean J Anesthesiol. 2011 Jul;61(1):63-8. doi: 10.4097/kjae.2011.61.1.63. Epub 
      2011 Jul 17.