PMID- 21861761
OWN - NLM
STAT- MEDLINE
DCOM- 20121002
LR  - 20211020
IS  - 1557-8534 (Electronic)
IS  - 1547-3287 (Print)
IS  - 1547-3287 (Linking)
VI  - 21
IP  - 9
DP  - 2012 Jun 10
TI  - Effects of intrabone marrow-bone marrow transplantation plus adult thymus 
      transplantation on survival of mice bearing leukemia.
PG  - 1441-8
LID - 10.1089/scd.2011.0358 [doi]
AB  - We recently found that allogeneic intrabone marrow-bone marrow transplantation 
      (IBM-BMT) plus adult thymus transplantation (ATT) from the same donor is 
      effective in mice bearing solid tumors. In the current study, we examined the 
      effects of this strategy on the survival of mice with leukemia. One week after 
      intravenous injection of 1x10(6) leukemic cells (EL-4, H-2(b)) into 8-week-old B6 
      (H-2(b)) mice, the mice were 8 Gy irradiated and transplanted with 1x10(7) bone 
      marrow cells (BMCs) from 8-week-old BALB/c mice (H-2(d)) by IBM-BMT with or 
      without donor lymphocyte infusion (DLI) or ATT. All the mice without treatment 
      died within 70 days after injection of EL-4. About 40% of those treated with 
      IBM-BMT alone died within 100 days due to tumor relapse. In contrast, those 
      treated with IBM-BMT+DLI or ATT showed the longest survival rate without relapse 
      of leukemia. In addition, the former showed less graft versus host disease (GVHD) 
      than the latter. The mice treated with IBM-BMT+ATT also showed an intermediate 
      percentage of effector memory (EM) and central memory (CM) cells between those 
      treated with BMT alone and those treated with IBM-BMT+DLI. The numbers and 
      functions of T cells increased in those treated with IBM-BMT+ATT with 
      interleukin-2 and interferon-gamma production. These results suggest that IBM-BMT+ATT 
      is effective in the treatment of leukemia with strong graft versus leukemia 
      without increased risk of GVHD.
FAU - Zhang, Yuming
AU  - Zhang Y
AD  - Department of Pediatrics, Nanfang Hospital, Guangzhou, China.
FAU - Hosaka, Naoki
AU  - Hosaka N
FAU - Cui, Yunze
AU  - Cui Y
FAU - Shi, Ming
AU  - Shi M
FAU - Li, Ming
AU  - Li M
FAU - Li, Qing
AU  - Li Q
FAU - Ikehara, Susumu
AU  - Ikehara S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111019
PL  - United States
TA  - Stem Cells Dev
JT  - Stem cells and development
JID - 101197107
RN  - 0 (Interleukin-2)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Animals
MH  - *Bone Marrow Transplantation
MH  - Female
MH  - Graft vs Host Disease/immunology/metabolism/pathology/therapy
MH  - Immunologic Memory
MH  - Interferon-gamma/immunology/metabolism
MH  - Interleukin-2/immunology/metabolism
MH  - Leukemia/immunology/metabolism/pathology/*therapy
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Neoplasms, Experimental
MH  - Thymus Gland/immunology/metabolism/pathology/*transplantation
MH  - Transplantation, Homologous
PMC - PMC3359636
EDAT- 2011/08/25 06:00
MHDA- 2012/10/04 06:00
PMCR- 2011/08/23
CRDT- 2011/08/25 06:00
PHST- 2011/08/25 06:00 [entrez]
PHST- 2011/08/25 06:00 [pubmed]
PHST- 2012/10/04 06:00 [medline]
PHST- 2011/08/23 00:00 [pmc-release]
AID - 10.1089/scd.2011.0358 [pii]
AID - 10.1089/scd.2011.0358 [doi]
PST - ppublish
SO  - Stem Cells Dev. 2012 Jun 10;21(9):1441-8. doi: 10.1089/scd.2011.0358. Epub 2011 
      Oct 19.