PMID- 21861923
OWN - NLM
STAT- MEDLINE
DCOM- 20120123
LR  - 20211020
IS  - 1471-2377 (Electronic)
IS  - 1471-2377 (Linking)
VI  - 11
DP  - 2011 Aug 24
TI  - The determinants of stroke phenotypes were different from the predictors (CHADS2 
      and CHA2DS2-VASc) of stroke in patients with atrial fibrillation: a comprehensive 
      approach.
PG  - 107
LID - 10.1186/1471-2377-11-107 [doi]
AB  - BACKGROUND: Atrial fibrillation (AF) is a leading cause of fatal ischemic stroke. 
      It was recently reported that international normalized ratio (INR) levels were 
      associated with infarct volumes. However, factors other than INR levels that 
      affect stroke phenotypes are largely unknown. Therefore, we evaluated the 
      determinants of stroke phenotypes (pattern and volume) among patients with AF who 
      were not adequately anticoagulated. METHODS: We analyzed data pertaining to 
      consecutive AF patients admitted over a 6-year period with acute MCA territory 
      infarcts. We divided the patients according to DWI (diffusion-weighted imaging) 
      lesion volumes and patterns, and the relationship between stroke predictors (the 
      CHADS2 and CHA2DS2-VASc score), systemic, and local factors and each stroke 
      phenotype were then evaluated. RESULTS: The stroke phenotypes varied among 231 
      patients (admission INR median 1.06, interquartile range (IQR) 1.00-1.14). 
      Specifically, (1) the DWI lesion volumes ranged from 0.04-338.62 ml (median 11.86 
      ml; IQR, 3.07-44.20 ml) and (2) 46 patients had a territorial infarct pattern, 
      118 had a lobar/deep pattern and 67 had a small scattered pattern. Multivariate 
      testing revealed that the CHADS2 and CHA2DS2-VASc score were not related to 
      either stroke phenotype. Additionally, the prior use of antiplatelet agents was 
      not related to the stroke phenotypes. Congestive heart failure and diastolic 
      dysfunction were not associated with stroke phenotypes. CONCLUSIONS: The results 
      of this study indicated that the determinants of stroke phenotypes were different 
      from the predictors (i.e., CHADS2 and CHA2DS2-VASc score) of stroke in patients 
      with AF.
FAU - Oh, Semi
AU  - Oh S
AD  - Department of Neurology, Stroke and Cerebrovascular Centre, Samsung Medical 
      Centre, Sungkyunkwan University, South Korea.
FAU - Kim, Suk Jae
AU  - Kim SJ
FAU - Ryu, Soo-Kyoung
AU  - Ryu SK
FAU - Kim, Gyeong-Moon
AU  - Kim GM
FAU - Chung, Chin Sang
AU  - Chung CS
FAU - Lee, Kwang Ho
AU  - Lee KH
FAU - Bang, Oh Young
AU  - Bang OY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110824
PL  - England
TA  - BMC Neurol
JT  - BMC neurology
JID - 100968555
RN  - 0 (Anticoagulants)
SB  - IM
MH  - Aged
MH  - Anticoagulants/therapeutic use
MH  - Atrial Fibrillation/*complications/drug therapy
MH  - Brain/pathology
MH  - Diffusion Magnetic Resonance Imaging/methods/statistics & numerical data
MH  - Female
MH  - Humans
MH  - International Normalized Ratio
MH  - Male
MH  - Middle Aged
MH  - Phenotype
MH  - Predictive Value of Tests
MH  - Risk Factors
MH  - *Severity of Illness Index
MH  - Stroke/complications/*diagnosis/drug therapy/pathology
PMC - PMC3174877
EDAT- 2011/08/25 06:00
MHDA- 2012/01/24 06:00
PMCR- 2011/08/24
CRDT- 2011/08/25 06:00
PHST- 2011/06/09 00:00 [received]
PHST- 2011/08/24 00:00 [accepted]
PHST- 2011/08/25 06:00 [entrez]
PHST- 2011/08/25 06:00 [pubmed]
PHST- 2012/01/24 06:00 [medline]
PHST- 2011/08/24 00:00 [pmc-release]
AID - 1471-2377-11-107 [pii]
AID - 10.1186/1471-2377-11-107 [doi]
PST - epublish
SO  - BMC Neurol. 2011 Aug 24;11:107. doi: 10.1186/1471-2377-11-107.