PMID- 21862646
OWN - NLM
STAT- MEDLINE
DCOM- 20111213
LR  - 20211020
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Print)
IS  - 0146-0404 (Linking)
VI  - 52
IP  - 10
DP  - 2011 Sep 29
TI  - Simple estimation of clinically relevant lesion volumes using spectral 
      domain-optical coherence tomography in neovascular age-related macular 
      degeneration.
PG  - 7792-8
LID - 10.1167/iovs.11-8023 [doi]
AB  - PURPOSE: To evaluate simple methods of estimating the volume of clinically 
      relevant features in neovascular age-related macular degeneration (NVAMD) using 
      spectral domain-optical coherence tomography (SD-OCT). METHODS: Using a database 
      of NVAMD cases imaged with macular cube (512 A-scans x 128 B-scans) SD-OCT scans, 
      the authors retrospectively selected visits where cystoid macular edema (CME), 
      subretinal fluid (SRF), or pigment epithelial detachments (PEDs) were evident. 
      Patients with single visits were analyzed in the cross-sectional analysis (CSA) 
      and those with a baseline visit and three or more follow-up visits in the 
      longitudinal analysis (LA). The volume of each feature was measured by manual 
      grading using validated grading software. Simplified measurements for each 
      feature included: number of B-scans or A-scans involved and maximum height. 
      Automated measurements of total macular volume and foveal central subfield were 
      also collected from each machine. Correlations were performed between the volumes 
      measured with 3D-OCTOR, automated measurements, and the simplified measures. 
      RESULTS: Forty-five visits for 25 patients were included in this study: 26 cube 
      scans from 26 eyes of 25 patients in the CSA and 24 scans from 5 eyes of 5 
      patients in the LA. The simplified measures that correlated best with manual 
      grading in the CSA group were maximum lesion height for CME (r(2) value = 0.96) and 
      B-scan count for SRF and PED volume (r(2) values of 0.88 and 0.70). In the LA 
      group, intervisit differences were correlated. Change in B-scan count correlated 
      well with change in SRF volume (r(2) = 0.97), whereas change in maximum height 
      correlated with change in CME and PED volume (r(2) = 0.98 and 0.43, respectively). 
      CONCLUSIONS: These data suggest that simplified estimators of some NVAMD lesion 
      volumes exist and are accessible by clinicians without the need for specialized 
      software or time-consuming manual segmentation. These simple approaches could 
      enhance quantitative disease monitoring strategies in clinical trials and 
      clinical practice.
FAU - Heussen, Florian M
AU  - Heussen FM
AD  - Doheny Eye Institute and the Department of Ophthalmology, Keck School of Medicine 
      of the University of Southern California, Los Angeles, California, USA.
FAU - Ouyang, Yanling
AU  - Ouyang Y
FAU - Sadda, Srinivas R
AU  - Sadda SR
FAU - Walsh, Alexander C
AU  - Walsh AC
LA  - eng
GR  - P30 EY003040/EY/NEI NIH HHS/United States
GR  - R01 EY014375/EY/NEI NIH HHS/United States
GR  - EY03040/EY/NEI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110929
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Macular Edema/*diagnosis
MH  - Male
MH  - Retinal Detachment/*diagnosis
MH  - Retinal Pigment Epithelium/*pathology
MH  - Retrospective Studies
MH  - Sensitivity and Specificity
MH  - *Subretinal Fluid
MH  - Tomography, Optical Coherence/*methods
MH  - Wet Macular Degeneration/*diagnosis
PMC - PMC3183988
EDAT- 2011/08/25 06:00
MHDA- 2011/12/14 06:00
PMCR- 2012/03/01
CRDT- 2011/08/25 06:00
PHST- 2011/08/25 06:00 [entrez]
PHST- 2011/08/25 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
PHST- 2012/03/01 00:00 [pmc-release]
AID - iovs.11-8023 [pii]
AID - 11-8023 [pii]
AID - 10.1167/iovs.11-8023 [doi]
PST - epublish
SO  - Invest Ophthalmol Vis Sci. 2011 Sep 29;52(10):7792-8. doi: 10.1167/iovs.11-8023.