PMID- 21864160
OWN - NLM
STAT- MEDLINE
DCOM- 20120202
LR  - 20220409
IS  - 1557-7465 (Electronic)
IS  - 1079-9907 (Linking)
VI  - 31
IP  - 10
DP  - 2011 Oct
TI  - Interleukin-18: a mediator of inflammation and angiogenesis in rheumatoid 
      arthritis.
PG  - 745-51
LID - 10.1089/jir.2011.0050 [doi]
AB  - Interleukin-18 (IL-18) is a highly regulated inflammatory cytokine that is 
      elevated in synovial tissues and synovial fluids of patients with rheumatoid 
      arthritis (RA) compared with patients with osteoarthritis (OA) and patients with 
      other arthropathies. Within the RA joint, IL-18 can contribute to the 
      inflammatory process by inducing leukocyte extravasation through upregulation of 
      endothelial cell adhesion molecules, the release of chemokines from RA synovial 
      fibroblasts, and directly as a monocytes, lymphocyte, and neutrophil 
      chemoattractant. IL-18 can also help maintain and develop the inflammatory pannus 
      by inducing endothelial cell migration and angiogenesis. IL-18 does this directly 
      by binding and activating endothelial cells and indirectly by inducing RA 
      synovial fibroblasts to produce angiogenic chemokines and vascular endothelial 
      growth factor. IL-18 is present in RA synovial fluid in high levels, where it 
      functions as an angiogenic mediator and leukocyte chemoattractant. IL-18 mediates 
      all these inflammatory processes by binding to its receptor, IL-18 receptor, and 
      initiating the activation of different signaling cascades leading to changes in 
      target cells gene expression and behavior. IL-18 has been identified as a 
      potential therapeutic target in the treatment of RA.
FAU - Volin, Michael V
AU  - Volin MV
AD  - Department of Microbiology and Immunology, Chicago College of Osteopathic 
      Medicine, Midwestern University, Downers Grove, Illinois, USA.
FAU - Koch, Alisa E
AU  - Koch AE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110824
PL  - United States
TA  - J Interferon Cytokine Res
JT  - Journal of interferon & cytokine research : the official journal of the 
      International Society for Interferon and Cytokine Research
JID - 9507088
RN  - 0 (Angiogenesis Inducing Agents)
RN  - 0 (Chemokines)
RN  - 0 (Interleukin-18)
RN  - 0 (Receptors, Interleukin-18)
SB  - IM
MH  - Angiogenesis Inducing Agents/*immunology
MH  - Animals
MH  - Arthritis, Rheumatoid/*immunology/pathology/therapy
MH  - Cell Movement/*immunology
MH  - Chemokines/immunology
MH  - Endothelial Cells/*immunology/pathology
MH  - Fibroblasts/immunology/pathology
MH  - Gene Expression Regulation/immunology
MH  - Humans
MH  - Inflammation/immunology/pathology/therapy
MH  - Interleukin-18/*immunology
MH  - Neovascularization, Pathologic/*immunology/pathology/therapy
MH  - Receptors, Interleukin-18/immunology
MH  - Signal Transduction/immunology
MH  - Synovial Membrane/immunology/pathology
EDAT- 2011/08/26 06:00
MHDA- 2012/02/03 06:00
CRDT- 2011/08/26 06:00
PHST- 2011/08/26 06:00 [entrez]
PHST- 2011/08/26 06:00 [pubmed]
PHST- 2012/02/03 06:00 [medline]
AID - 10.1089/jir.2011.0050 [doi]
PST - ppublish
SO  - J Interferon Cytokine Res. 2011 Oct;31(10):745-51. doi: 10.1089/jir.2011.0050. 
      Epub 2011 Aug 24.