PMID- 21865482
OWN - NLM
STAT- MEDLINE
DCOM- 20111207
LR  - 20221207
IS  - 1530-8561 (Electronic)
IS  - 0009-9147 (Linking)
VI  - 57
IP  - 10
DP  - 2011 Oct
TI  - Serum concentrations of insulin-like growth factor (IGF)-1 and IGF binding 
      protein-3 (IGFBP-3), IGF-1/IGFBP-3 ratio, and markers of bone turnover: reference 
      values for French children and adolescents and z-score comparability with other 
      references.
PG  - 1424-35
LID - 10.1373/clinchem.2011.169466 [doi]
AB  - BACKGROUND: A reference model for converting serum growth factor and bone 
      metabolism markers into an SD score (SDS) is required for clinical practice. We 
      aimed to establish reference values of serum insulin-like growth factor-1 (IGF-1) 
      and IGF binding protein 3 (IGFBP-3) concentrations and bone metabolism markers in 
      French children, to generate a model for converting values into SDS for age, sex, 
      and pubertal stage. METHODS: We carried out a cross-sectional study of 1119 
      healthy white children ages 6-20 years. We assessed concentrations of serum 
      IGF-1, IGFBP-3, carboxyterminal telopeptide alpha1 chain of type I collagen 
      (CrossLaps), and bone alkaline phosphatase concentrations and height, weight, and 
      pubertal stage, and used semiparametric regression to develop a model. RESULTS: A 
      single regression model to calculate the SDSs with an online calculator was 
      provided. A positive relationship was found between SDS for serum IGF-1 and 
      IGFBP-3, IGF/IGFBP-3 mol/L ratio, and anthropometric parameters (P < 0.0001), 
      with slightly greater effects observed for height than for body mass index (BMI). 
      There was a negative relationship between serum CrossLaps concentration and BMI, 
      and a positive relationship between serum CrossLaps concentration and height. A 
      comparison of serum IGF-1 reference databases for children showed marked 
      variation as a function of age and pubertal group; smooth changes with age and 
      puberty were observed only in our model. CONCLUSIONS: This new model for the 
      assessment of SDS reference values specific for age, sex, and pubertal stage may 
      help to increase the diagnostic power of these parameters for the assessment of 
      growth and bone metabolism disorders. This study also provides information about 
      the physiological role of height and BMI for the interpretation of these 
      parameters.
FAU - Alberti, Corinne
AU  - Alberti C
AD  - INSERM, CIC-EC CIE5, Paris, France.
FAU - Chevenne, Didier
AU  - Chevenne D
FAU - Mercat, Isabelle
AU  - Mercat I
FAU - Josserand, Emilie
AU  - Josserand E
FAU - Armoogum-Boizeau, Priscilla
AU  - Armoogum-Boizeau P
FAU - Tichet, Jean
AU  - Tichet J
FAU - Leger, Juliane
AU  - Leger J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110824
PL  - England
TA  - Clin Chem
JT  - Clinical chemistry
JID - 9421549
RN  - 0 (Biomarkers)
RN  - 0 (Insulin-Like Growth Factor Binding Protein 3)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - Adolescent
MH  - Age Factors
MH  - Biomarkers/blood
MH  - Bone and Bones/*metabolism
MH  - Child
MH  - Cross-Sectional Studies
MH  - Female
MH  - France
MH  - Humans
MH  - Insulin-Like Growth Factor Binding Protein 3/*blood
MH  - Insulin-Like Growth Factor I/*analysis
MH  - Male
MH  - Models, Biological
MH  - Reference Values
MH  - Regression Analysis
MH  - Serum
MH  - Sex Factors
MH  - White People
MH  - Young Adult
EDAT- 2011/08/26 06:00
MHDA- 2011/12/13 00:00
CRDT- 2011/08/26 06:00
PHST- 2011/08/26 06:00 [entrez]
PHST- 2011/08/26 06:00 [pubmed]
PHST- 2011/12/13 00:00 [medline]
AID - clinchem.2011.169466 [pii]
AID - 10.1373/clinchem.2011.169466 [doi]
PST - ppublish
SO  - Clin Chem. 2011 Oct;57(10):1424-35. doi: 10.1373/clinchem.2011.169466. Epub 2011 
      Aug 24.