PMID- 2186570
OWN - NLM
STAT- MEDLINE
DCOM- 19900614
LR  - 20061115
IS  - 0042-773X (Print)
IS  - 0042-773X (Linking)
VI  - 36
IP  - 2
DP  - 1990 Feb
TI  - [Manifestations of dysfunction of the proximal tubules after intravenous 
      urography].
PG  - 141-6
AB  - The aim of the work was to investigate functional changes of tubular cells after 
      i.v. urography. As evidence the authors used assessment of urinary levels of 
      membrane-bound enzymes--alkaline phosphatase (AP), gamma-glutamyl-transpeptidase, 
      lysosomally bound enzymes N-acetyl-beta-D-glucosaminidase and its isoenzyme B and 
      the low molecular protein, beta-2-microglobulin. The above substance were 
      assessed in 15 patients with different nephropathies where i.v. urography was 
      indicated. The examinations were made in 24-hour urine samples before i.v. 
      urography and in two 24-hour samples after administration of the contrast 
      substance. In all patients a significant rise of tubular enzyme excretion was 
      observated as well as of beta-2-microglobulin. The greatest rise was recorded in 
      alkaline phosphatase in the second sample after administration of the contrast 
      substance (432% of the initial value). Beta-2-microglobulin and 
      N-acetyl-D-glucoseaminidase rose already during the first collection period (B2M 
      to 357% and NAG to 181% of the initial values). The authors conclude that i.v. 
      urography made by hyperosmolar iodinated preparations (Verografin, Iodamide) 
      significantly affects the function and integrity of the proximal tubule. The 
      applied spectrum of examinations is suitable also for further investigations of 
      the effect of contrast substances on cells of the proximal renal tubule.
FAU - Haragsim, L
AU  - Haragsim L
AD  - Ustav pro toxikologii FVL UK, Praha.
FAU - Hatle, K
AU  - Hatle K
FAU - Stolba, P
AU  - Stolba P
FAU - Nedvidkova, J
AU  - Nedvidkova J
FAU - Nemecek, K
AU  - Nemecek K
FAU - Knotkova, V
AU  - Knotkova V
FAU - Sekava, J
AU  - Sekava J
LA  - cze
PT  - English Abstract
PT  - Journal Article
TT  - Projevy dysfunkce proximalniho tubulu po intravenozni urografii.
PL  - Czech Republic
TA  - Vnitr Lek
JT  - Vnitrni lekarstvi
JID - 0413602
RN  - 0 (Contrast Media)
RN  - 0 (Enzymes)
RN  - 0 (beta 2-Microglobulin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Contrast Media/*administration & dosage/adverse effects
MH  - Enzymes/urine
MH  - Female
MH  - Humans
MH  - Injections, Intravenous
MH  - Kidney Function Tests
MH  - Kidney Tubules, Proximal/drug effects/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - Urography/*adverse effects
MH  - beta 2-Microglobulin/urine
EDAT- 1990/02/01 00:00
MHDA- 1990/02/01 00:01
CRDT- 1990/02/01 00:00
PHST- 1990/02/01 00:00 [pubmed]
PHST- 1990/02/01 00:01 [medline]
PHST- 1990/02/01 00:00 [entrez]
PST - ppublish
SO  - Vnitr Lek. 1990 Feb;36(2):141-6.