PMID- 21866887
OWN - NLM
STAT- MEDLINE
DCOM- 20111212
LR  - 20180924
IS  - 1520-4804 (Electronic)
IS  - 0022-2623 (Linking)
VI  - 54
IP  - 19
DP  - 2011 Oct 13
TI  - Cationic derivatives of dextran and hydroxypropylcellulose as novel potential 
      heparin antagonists.
PG  - 6586-96
LID - 10.1021/jm200380w [doi]
AB  - Cationic derivatives of dextran (Dex) and hydroxypropylcellulose (HPC) were 
      studied as potential alternatives of protamine sulfate (PS) used in the reversal 
      of anticoagulant activity of heparin. The modification was performed by the 
      attachment of cationic groups to the Dex main chain or by grafting short side 
      chains of a polycation onto HPC. The cationic derivatives of these 
      polysaccharides were found to bind heparin with the efficiency increasing with 
      growing degree of cationic modification. The degree of cationic modification and 
      consequently the zeta potential of the polymers do not have to be high to achieve 
      effective heparin binding. The size of the complexes of cationic Dex with 
      unfractionated heparin (UFH) is a few micrometers. For complexes of cationic HPC 
      and UFH the size is much below 1 mum, both below and above the lower critical 
      solution temperature of HPC. None of the cationic polysaccharides studied caused 
      hemolysis. The concentrations of the polymers inducing the aggregation of human 
      erythrocytes in vitro were determined.
FAU - Kaminski, Kamil
AU  - Kaminski K
AD  - Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Krakow, 
      Poland.
FAU - Plonka, Monika
AU  - Plonka M
FAU - Ciejka, Justyna
AU  - Ciejka J
FAU - Szczubialka, Krzysztof
AU  - Szczubialka K
FAU - Nowakowska, Maria
AU  - Nowakowska M
FAU - Lorkowska, Barbara
AU  - Lorkowska B
FAU - Korbut, Ryszard
AU  - Korbut R
FAU - Lach, Radoslaw
AU  - Lach R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110906
PL  - United States
TA  - J Med Chem
JT  - Journal of medicinal chemistry
JID - 9716531
RN  - 0 (Cations)
RN  - 0 (Dextrans)
RN  - 0 (Heparin Antagonists)
RN  - 0 (Quaternary Ammonium Compounds)
RN  - 9004-34-6 (Cellulose)
RN  - 9005-49-6 (Heparin)
RN  - 9XZ8H6N6OH (hydroxypropylcellulose)
SB  - IM
MH  - Cations
MH  - Cellulose/*analogs & derivatives/chemical synthesis/chemistry/pharmacology
MH  - Dextrans/*chemical synthesis/chemistry/pharmacology
MH  - Erythrocyte Aggregation/drug effects
MH  - Hemolysis
MH  - Heparin/chemistry
MH  - Heparin Antagonists/*chemical synthesis/chemistry/pharmacology
MH  - Humans
MH  - In Vitro Techniques
MH  - Light
MH  - Quaternary Ammonium Compounds/*chemical synthesis/chemistry/pharmacology
MH  - Scattering, Radiation
MH  - Structure-Activity Relationship
EDAT- 2011/08/27 06:00
MHDA- 2011/12/14 06:00
CRDT- 2011/08/27 06:00
PHST- 2011/08/27 06:00 [entrez]
PHST- 2011/08/27 06:00 [pubmed]
PHST- 2011/12/14 06:00 [medline]
AID - 10.1021/jm200380w [doi]
PST - ppublish
SO  - J Med Chem. 2011 Oct 13;54(19):6586-96. doi: 10.1021/jm200380w. Epub 2011 Sep 6.