PMID- 21868018
OWN - NLM
STAT- MEDLINE
DCOM- 20120227
LR  - 20111101
IS  - 1879-1484 (Electronic)
IS  - 0021-9150 (Linking)
VI  - 219
IP  - 1
DP  - 2011 Nov
TI  - Genetic variants of the monocyte chemoattractant protein-1 gene and its receptor 
      CCR2 and risk of coronary artery disease: a meta-analysis.
PG  - 224-30
LID - 10.1016/j.atherosclerosis.2011.07.116 [doi]
AB  - OBJECTIVE: Monocyte chemoattractant protein-1 (MCP-1) and its receptor chemokine 
      (C-C motif) receptor 2 (CCR2) are implicated in promoting atherosclerosis. Many 
      studies have searched the association between variants of the MCP-1 gene or CCR2 
      gene and risk of coronary artery disease (CAD), but the results are inconsistent. 
      METHODS: We conducted a meta-analysis of 20 publications including 24 studies on 
      2 genetic variants [A-2518G in the MCP-1 and V64I in the CCR2] published before 
      January 2011, including a total of 9844 patients with CAD and 11,821 controls. 
      Publication bias and heterogeneity among studies were explored. RESULTS: In a 
      combined analysis, the pooled OR for CAD of the -2518G allele was 1.42 (95%CI: 
      1.06-1.92) compared to wild-type A allele under a recessive model in Caucasian 
      group, but there is an indication of publication bias and heterogeneity among the 
      9 studies. When the analyses were restricted to 2 large studies (n>/=500 cases), 
      the pooled OR was 1.08 (95%CI: 0.85-1.37). Our analyses detected a possibility of 
      publication bias with an overestimate of the true association by smaller studies. 
      A meta-analysis of studies on the CCR2 V64I variant showed no significant 
      association with CAD, the pooled OR of 64I was 1.27 (95%CI: 0.81-1.99) in 
      recessive model and 1.06 (95%CI: 0.95-1.19) in dominant model, respectively. 
      CONCLUSIONS: The results indicate that MCP-1-2518G allele had probably increased 
      risk of CAD in Caucasian but this is likely to be due to publication bias and 
      insufficient sample size. The CCR2 V64I has not been found any association with 
      CAD.
CI  - Copyright A(c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Wang, Yuyao
AU  - Wang Y
AD  - Key Laboratory for Clinical Cardiovascular Genetics & Sino-German Laboratory for 
      Molecular Medicine, Cardiovascular Institute & FuWai Hospital, Chinese Academy of 
      Medical Sciences & Peking Union Medical College, Beijing, China.
FAU - Zhang, Weili
AU  - Zhang W
FAU - Li, Shaohua
AU  - Li S
FAU - Song, Weihua
AU  - Song W
FAU - Chen, Jingzhou
AU  - Chen J
FAU - Hui, Rutai
AU  - Hui R
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20110804
PL  - Ireland
TA  - Atherosclerosis
JT  - Atherosclerosis
JID - 0242543
RN  - 0 (CCL2 protein, human)
RN  - 0 (CCR2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Receptors, CCR2)
SB  - IM
MH  - Alleles
MH  - Chemokine CCL2/*genetics
MH  - Coronary Artery Disease/*genetics/metabolism
MH  - Female
MH  - Humans
MH  - Male
MH  - Meta-Analysis as Topic
MH  - Publication Bias
MH  - Receptors, CCR2/*genetics
MH  - Research Design
MH  - Risk Factors
MH  - Sample Size
EDAT- 2011/08/27 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/08/27 06:00
PHST- 2011/05/06 00:00 [received]
PHST- 2011/07/15 00:00 [revised]
PHST- 2011/07/24 00:00 [accepted]
PHST- 2011/08/27 06:00 [entrez]
PHST- 2011/08/27 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - S0021-9150(11)00737-4 [pii]
AID - 10.1016/j.atherosclerosis.2011.07.116 [doi]
PST - ppublish
SO  - Atherosclerosis. 2011 Nov;219(1):224-30. doi: 
      10.1016/j.atherosclerosis.2011.07.116. Epub 2011 Aug 4.