PMID- 2187017
OWN - NLM
STAT- MEDLINE
DCOM- 19900619
LR  - 20190918
IS  - 0271-9142 (Print)
IS  - 0271-9142 (Linking)
VI  - 10
IP  - 2
DP  - 1990 Mar
TI  - Intravenous immunoglobulin (IVIG) for the therapy of autoimmune disorders.
PG  - 81-9
AB  - The weight of evidence from numerous clinical studies supports the use of IVIG, 
      particularly at higher doses, in the treatment of a wide range of autoimmune 
      disorders. Extensive experience has documented the safety of IVIG therapy but its 
      present relatively high cost necessitates firmly establishing its efficacy. There 
      is an acute need to define those disease states where IVIG is indicated and 
      effective. Large-scale, possibly multicentered, clinical trials employing 
      rigorous controls will resolve these questions. Concurrent fundamental 
      immunologic studies will elucidate the mechanisms underlying the clinical 
      effects. We are experiencing an exciting new era of effective immunotherapies and 
      intravenous gamma-globulin preparations have already secured an important place 
      in the therapeutic armamentarium. While one must guard against unsubstantiated 
      applications, critical exploration of new uses for this unique product is 
      warranted.
FAU - Schwartz, S A
AU  - Schwartz SA
AD  - Department of Pediatrics, University of Michigan, Ann Arbor 48109-2029.
LA  - eng
GR  - CA35922/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - Netherlands
TA  - J Clin Immunol
JT  - Journal of clinical immunology
JID - 8102137
RN  - 0 (Immunoglobulins)
SB  - IM
MH  - Autoimmune Diseases/*therapy
MH  - Humans
MH  - Immunization, Passive/*methods
MH  - Immunoglobulins/*administration & dosage
MH  - Infusions, Intravenous
RF  - 81
EDAT- 1990/03/01 00:00
MHDA- 1990/03/01 00:01
CRDT- 1990/03/01 00:00
PHST- 1990/03/01 00:00 [pubmed]
PHST- 1990/03/01 00:01 [medline]
PHST- 1990/03/01 00:00 [entrez]
AID - 10.1007/BF00918189 [doi]
PST - ppublish
SO  - J Clin Immunol. 1990 Mar;10(2):81-9. doi: 10.1007/BF00918189.