PMID- 21870300
OWN - NLM
STAT- MEDLINE
DCOM- 20111228
LR  - 20180802
IS  - 1424-3997 (Electronic)
IS  - 0036-7672 (Linking)
VI  - 141
DP  - 2011
TI  - No association between herpes simplex virus 1 and cardiac myxoma.
PG  - w13223
LID - 10.4414/smw.2011.13223 [doi]
AB  - PRINCIPLES: Cardiac myxoma is the most commonly diagnosed cardiac tumour. 
      Infection of herpes simplex virus 1 (HSV1) has been postulated to be a factor for 
      this pathologic entity. The aim of the current study was to evaluate the 
      association between HSV 1 and myxoma occurrence. METHODS: Between 1965 and 2005, 
      70 patients (36 female, mean age: 52.6 years) underwent a resection of myxoma. 
      Selected variables such as hospital mortality and morbidity were studied. A 
      follow-up (FU; mean FU time: 138 +/- 83 months) was obtained (76% complete). 
      Immunohistological studies with monoclonal antibodies against HSV type 1 were 
      performed on tumour biopsies of 40 patients. RESULTS: The mean age was 53 +/- 16 
      years (range 23 to 84 years, 51% female). Of the investigated population, 31 
      (44%) were in New York Heart Association (NYHA) class III-IV. Mitral valve 
      stenosis was identified in 14 patients (20%), and in 25 (36%) patients mitral 
      valve was insufficient. During hospitalisation 3 patients suffered from a 
      transient neurological disorder, and in addition to myxoma resection 18 (25.7%) 
      patients had to undergo an additional intervention. The overall survival rate was 
      91% at 40 years. There was no early postoperative mortality in follow-up, 
      although 4 patients died and 2 patients had been re-operated on for recurrent 
      myxomas after 2 and 9 years. Immunohistology revealed no positive signals for 
      HSV-1 antigens among the 40 analysed cases. CONCLUSION: Complete surgical 
      resection, septum included, was the treatment of choice and mandatory to prevent 
      relapse. Peri-operative morbidity and mortality over 40 years remained low, and 
      no association between HSV infection and occurrence of cardiac myxoma was found.
FAU - Schurr, Ulrich P
AU  - Schurr UP
AD  - Department of Cardiac Surgery, Triemli Hospital, Zurich, Switzerland. 
      Ulrich.Schurr@triemli.stzh.ch
FAU - Berdajs, Denis A
AU  - Berdajs DA
FAU - Bode, Beate
AU  - Bode B
FAU - Dzemali, Omer
AU  - Dzemali O
FAU - Emmert, Maximilian Y
AU  - Emmert MY
FAU - Genoni, Michele
AU  - Genoni M
LA  - eng
PT  - Journal Article
DEP - 20110826
PL  - Switzerland
TA  - Swiss Med Wkly
JT  - Swiss medical weekly
JID - 100970884
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Neoplasms/pathology/surgery/*virology
MH  - Herpesviridae Infections/*complications
MH  - *Herpesvirus 1, Human
MH  - Humans
MH  - Immunohistochemistry
MH  - Male
MH  - Middle Aged
MH  - Myxoma/pathology/surgery/*virology
MH  - *Neoplasm Recurrence, Local
MH  - Young Adult
EDAT- 2011/08/27 06:00
MHDA- 2011/12/29 06:00
CRDT- 2011/08/27 06:00
PHST- 2011/08/27 06:00 [entrez]
PHST- 2011/08/27 06:00 [pubmed]
PHST- 2011/12/29 06:00 [medline]
AID - smw-13223 [pii]
AID - 10.4414/smw.2011.13223 [doi]
PST - epublish
SO  - Swiss Med Wkly. 2011 Aug 26;141:w13223. doi: 10.4414/smw.2011.13223. eCollection 
      2011.