PMID- 21870725
OWN - NLM
STAT- MEDLINE
DCOM- 20111114
LR  - 20141120
IS  - 0048-7848 (Print)
IS  - 0048-7848 (Linking)
VI  - 115
IP  - 2
DP  - 2011 Apr-Jun
TI  - Efficacy of Helicobacter pylori eradication therapy in cirrhotic patients with 
      peptic ulcer disease.
PG  - 367-74
AB  - Few studies have been focused on the role of Helicobacter pylori eradication in 
      cirrhotic patients with peptic ulcer and the reported results are conflicting. 
      AIM: To evaluate the efficacy of proton pump inhibitor (PPI)-based triple therapy 
      on peptic ulcer course in patients with liver cirrhosis. MATERIAL AND METHODS: 
      This prospective study was carried out in a tertiary-care hospital. Of the 63 
      consecutive cirrhotic patients with peptic ulcer identified by endoscopy 39 (22 
      males, 14 females, aged 53 to 62 years) entered the study. The patients with 
      peptic ulcer and H. pylori infection received eradication therapy, while H. 
      pylori negative patients received PPI treatment. H. pylori eradication was 
      confirmed by rapid urease test and histological examination. Follow-up 
      endoscopies were performed at 6 and 12 months. The patients with peptic ulcer 
      recurrence were treated with PPI. RESULTS: Of the 39 selected patients 22 (56.4%) 
      were H. pylori positive, and 17 (43.6%) were H. pylori negative. H. pylori was 
      eradicated in 63.6% (14/22) of the patients. During the follow-up period 2 H. 
      pylori negative patients died from variceal bleeding and hepatic encephalopathy, 
      respectively, and one H. pylori positive patient did not return for further 
      assessment). Ulcers recurring within 1 year were found in 14 of 36 (38.8%) 
      patients. Peptic ulcer recurred in 4 of 21 (19.0%) H. pylori positive patients 
      and in 10 of 15 (47.6%) H. pylori negative patients at study entry. Patients' age 
      (p = 0.018), Child-Pugh stage (p = 0.019), peptic ulcer site (p = 0.008), and H. 
      pylori negative status (p = 0.004) were significantly related to ulcer 
      recurrence. CONCLUSIONS: Eradication of H. pylori infection in patients with 
      liver cirrhosis and peptic ulcer disease could be helpful, but does not protect 
      all cirrhotic patients from peptic ulcer recurrence. Most relapsed ulcers were 
      gastric ulcers in H. pylori negative patients.
FAU - Mitrica, Dana
AU  - Mitrica D
AD  - Universitatii de Medicina si Farmacie Gr. T. Popa Iasi, Universitatea de Medicina 
      si Farmacie Gr. T. Popa Iasi, Facultatea de Medicina.
FAU - Plesa, Alina
AU  - Plesa A
FAU - Constantinescu, R
AU  - Constantinescu R
FAU - Drug, V
AU  - Drug V
FAU - Stanciu, C
AU  - Stanciu C
LA  - eng
PT  - Journal Article
PL  - Romania
TA  - Rev Med Chir Soc Med Nat Iasi
JT  - Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi
JID - 0413735
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Anti-Ulcer Agents)
RN  - 0 (Proton Pump Inhibitors)
RN  - KG60484QX9 (Omeprazole)
SB  - IM
MH  - Aged
MH  - Anti-Bacterial Agents/therapeutic use
MH  - Anti-Ulcer Agents/therapeutic use
MH  - Drug Therapy, Combination
MH  - Female
MH  - Follow-Up Studies
MH  - Helicobacter Infections/complications/*drug therapy
MH  - Helicobacter pylori/*drug effects/isolation & purification
MH  - Hospitals, University
MH  - Humans
MH  - Liver Cirrhosis/*complications
MH  - Male
MH  - Middle Aged
MH  - Omeprazole/therapeutic use
MH  - Peptic Ulcer/complications/drug therapy/*microbiology
MH  - Peptic Ulcer Hemorrhage/prevention & control
MH  - Prospective Studies
MH  - Proton Pump Inhibitors
MH  - Secondary Prevention
MH  - Treatment Outcome
EDAT- 2011/08/30 06:00
MHDA- 2011/11/15 06:00
CRDT- 2011/08/30 06:00
PHST- 2011/08/30 06:00 [entrez]
PHST- 2011/08/30 06:00 [pubmed]
PHST- 2011/11/15 06:00 [medline]
PST - ppublish
SO  - Rev Med Chir Soc Med Nat Iasi. 2011 Apr-Jun;115(2):367-74.