PMID- 21871552 OWN - NLM STAT- MEDLINE DCOM- 20120126 LR - 20211020 IS - 1873-6815 (Electronic) IS - 0531-5565 (Print) IS - 0531-5565 (Linking) VI - 46 IP - 11 DP - 2011 Nov TI - Design, recruitment, logistics, and data management of the GEHA (Genetics of Healthy Ageing) project. PG - 934-45 LID - 10.1016/j.exger.2011.08.005 [doi] AB - In 2004, the integrated European project GEHA (Genetics of Healthy Ageing) was initiated with the aim of identifying genes involved in healthy ageing and longevity. The first step in the project was the recruitment of more than 2500 pairs of siblings aged 90 years or more together with one younger control person from 15 areas in 11 European countries through a coordinated and standardised effort. A biological sample, preferably a blood sample, was collected from each participant, and basic physical and cognitive measures were obtained together with information about health, life style, and family composition. From 2004 to 2008 a total of 2535 families comprising 5319 nonagenarian siblings were identified and included in the project. In addition, 2548 younger control persons aged 50-75 years were recruited. A total of 2249 complete trios with blood samples from at least two old siblings and the younger control were formed and are available for genetic analyses (e.g. linkage studies and genome-wide association studies). Mortality follow-up improves the possibility of identifying families with the most extreme longevity phenotypes. With a mean follow-up time of 3.7 years the number of families with all participating siblings aged 95 years or more has increased by a factor of 5 to 750 families compared to when interviews were conducted. Thus, the GEHA project represents a unique source in the search for genes related to healthy ageing and longevity. CI - Copyright (c) 2011 Elsevier Inc. All rights reserved. FAU - Skytthe, A AU - Skytthe A AD - Epidemiology, Institute of Public Health, University of Southern Denmark, J B Winslows Vej 9B, Odense, Denmark. askytthe@health.sdu.dk FAU - Valensin, S AU - Valensin S FAU - Jeune, B AU - Jeune B FAU - Cevenini, E AU - Cevenini E FAU - Balard, F AU - Balard F FAU - Beekman, M AU - Beekman M FAU - Bezrukov, V AU - Bezrukov V FAU - Blanche, H AU - Blanche H FAU - Bolund, L AU - Bolund L FAU - Broczek, K AU - Broczek K FAU - Carru, C AU - Carru C FAU - Christensen, K AU - Christensen K FAU - Christiansen, L AU - Christiansen L FAU - Collerton, J C AU - Collerton JC FAU - Cotichini, R AU - Cotichini R FAU - de Craen, A J M AU - de Craen AJ FAU - Dato, S AU - Dato S FAU - Davies, K AU - Davies K FAU - De Benedictis, G AU - De Benedictis G FAU - Deiana, L AU - Deiana L FAU - Flachsbart, F AU - Flachsbart F FAU - Gampe, J AU - Gampe J FAU - Gilbault, C AU - Gilbault C FAU - Gonos, E S AU - Gonos ES FAU - Haimes, E AU - Haimes E FAU - Hervonen, A AU - Hervonen A FAU - Hurme, M A AU - Hurme MA FAU - Janiszewska, D AU - Janiszewska D FAU - Jylha, M AU - Jylha M FAU - Kirkwood, T B L AU - Kirkwood TB FAU - Kristensen, P AU - Kristensen P FAU - Laiho, P AU - Laiho P FAU - Leon, A AU - Leon A FAU - Marchisio, A AU - Marchisio A FAU - Masciulli, R AU - Masciulli R FAU - Nebel, A AU - Nebel A FAU - Passarino, G AU - Passarino G FAU - Pelicci, G AU - Pelicci G FAU - Peltonen, L AU - Peltonen L FAU - Perola, M AU - Perola M FAU - Poulain, M AU - Poulain M FAU - Rea, I M AU - Rea IM FAU - Remacle, J AU - Remacle J FAU - Robine, J M AU - Robine JM FAU - Schreiber, S AU - Schreiber S FAU - Scurti, M AU - Scurti M FAU - Sevini, F AU - Sevini F FAU - Sikora, E AU - Sikora E FAU - Skouteri, A AU - Skouteri A FAU - Slagboom, P E AU - Slagboom PE FAU - Spazzafumo, L AU - Spazzafumo L FAU - Stazi, M A AU - Stazi MA FAU - Toccaceli, V AU - Toccaceli V FAU - Toussaint, O AU - Toussaint O FAU - Tornwall, O AU - Tornwall O FAU - Vaupel, J W AU - Vaupel JW FAU - Voutetakis, K AU - Voutetakis K FAU - Franceschi, C AU - Franceschi C CN - GEHA consortium LA - eng GR - P01 AG008761/AG/NIA NIH HHS/United States GR - P01-AG08761/AG/NIA NIH HHS/United States PT - Journal Article PT - Multicenter Study PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20110816 PL - England TA - Exp Gerontol JT - Experimental gerontology JID - 0047061 SB - IM MH - Aged MH - Aged, 80 and over MH - Aging/*genetics MH - Cognition MH - Europe/epidemiology MH - Family MH - Female MH - Genetic Linkage MH - Genome-Wide Association Study MH - Humans MH - Life Style MH - Longevity/*genetics MH - Male MH - Middle Aged MH - *Patient Selection MH - *Research Design MH - Surveys and Questionnaires PMC - PMC3622890 MID - NIHMS454967 FIR - Andersen, S IR - Andersen S FIR - Bemer, E IR - Bemer E FIR - Berardelli, M IR - Berardelli M FIR - Blauw, G J IR - Blauw GJ FIR - Bodker, F IR - Bodker F FIR - Borm, S IR - Borm S FIR - Castaldi, M-H IR - Castaldi MH FIR - Celani, L IR - Celani L FIR - Christensen, G B IR - Christensen GB FIR - Christiansen, S E IR - Christiansen SE FIR - Clavel, A IR - Clavel A FIR - De Groot-Nys, M IR - De Groot-Nys M FIR - De Man, L W IR - De Man LW FIR - De Rango, F IR - De Rango F FIR - Debacq-Chainiaux, F IR - Debacq-Chainiaux F FIR - Dewit, F IR - Dewit F FIR - D'ippolito, C IR - D'ippolito C FIR - Ervasti, M IR - Ervasti M FIR - Facchini, R IR - Facchini R FIR - Fagnani, C IR - Fagnani C FIR - Faurobert, J IR - Faurobert J FIR - Ferrari, D IR - Ferrari D FIR - Frackowiak, B IR - Frackowiak B FIR - Frapsauce, A IR - Frapsauce A FIR - Frolich, M IR - Frolich M FIR - Granger, B IR - Granger B FIR - Hirviniemi, S IR - Hirviniemi S FIR - Hughes, J IR - Hughes J FIR - Jussila, M IR - Jussila M FIR - Kcholin, V IR - Kcholin V FIR - Kirik, V IR - Kirik V FIR - Klojgaard, S IR - Klojgaard S FIR - Knudsen, S IR - Knudsen S FIR - Knuuttila, H IR - Knuuttila H FIR - Kupisz-Urbanska, M IR - Kupisz-Urbanska M FIR - Lecomte, C IR - Lecomte C FIR - Locuratolo, C N IR - Locuratolo CN FIR - Maenpaa, K IR - Maenpaa K FIR - Marais, M IR - Marais M FIR - Mari, V IR - Mari V FIR - Marras, M IR - Marras M FIR - Martin, B IR - Martin B FIR - Martino, C IR - Martino C FIR - McNerlan, S IR - McNerlan S FIR - Meucci, K IR - Meucci K FIR - Milbradt, K IR - Milbradt K FIR - Mooijekind, I G J IR - Mooijekind IG FIR - Muradian, K IR - Muradian K FIR - Murphy, A IR - Murphy A FIR - Nielsen, L IR - Nielsen L FIR - Nikolaus, S IR - Nikolaus S FIR - Nistico, L IR - Nistico L FIR - Palmas, M G IR - Palmas MG FIR - Panourgia, M P IR - Panourgia MP FIR - Pascal, T IR - Pascal T FIR - Penna, L IR - Penna L FIR - Pes, G IR - Pes G FIR - Peters, U IR - Peters U FIR - Phelipot, M IR - Phelipot M FIR - Pini, E IR - Pini E FIR - Podkowka-Sieczka, R IR - Podkowka-Sieczka R FIR - Poletayeva, K IR - Poletayeva K FIR - Polyakov, A IR - Polyakov A FIR - Polyakova, I IR - Polyakova I FIR - Prokopenko, N IR - Prokopenko N FIR - Pulciani, S IR - Pulciani S FIR - Purcheddu, S IR - Purcheddu S FIR - Rasmussen, K M IR - Rasmussen KM FIR - Repo, J IR - Repo J FIR - Ricciardi, E IR - Ricciardi E FIR - Romieu, I IR - Romieu I FIR - Ronne, I IR - Ronne I FIR - Saarela, K IR - Saarela K FIR - Salemi, M IR - Salemi M FIR - Skaaning, J IR - Skaaning J FIR - Slynchak, P IR - Slynchak P FIR - Snoek, N IR - Snoek N FIR - Stelmakch, T IR - Stelmakch T FIR - Tango, F IR - Tango F FIR - Timonen, E IR - Timonen E FIR - Tomarevskaya, E IR - Tomarevskaya E FIR - Tuikkala, A IR - Tuikkala A FIR - Tuovinen, J IR - Tuovinen J FIR - Ustimenko, A IR - Ustimenko A FIR - Vaiserman, A IR - Vaiserman A FIR - Vallone, A IR - Vallone A FIR - Van Boxsel, T IR - Van Boxsel T FIR - Van der Breggen, R IR - Van der Breggen R FIR - Van der Star, M G H F IR - Van der Star MG FIR - Vandervelpen, G IR - Vandervelpen G FIR - Vavrik, G IR - Vavrik G FIR - Verkkonen, K IR - Verkkonen K FIR - von Eller-Eberstein, H IR - von Eller-Eberstein H FIR - Westendorp, R G J IR - Westendorp RG FIR - Widen, E IR - Widen E FIR - Yli-Hukkala, K IR - Yli-Hukkala K FIR - Aalto, A IR - Aalto A EDAT- 2011/08/30 06:00 MHDA- 2012/01/27 06:00 PMCR- 2013/04/11 CRDT- 2011/08/30 06:00 PHST- 2010/11/24 00:00 [received] PHST- 2011/07/09 00:00 [revised] PHST- 2011/08/10 00:00 [accepted] PHST- 2011/08/30 06:00 [entrez] PHST- 2011/08/30 06:00 [pubmed] PHST- 2012/01/27 06:00 [medline] PHST- 2013/04/11 00:00 [pmc-release] AID - S0531-5565(11)00204-X [pii] AID - 10.1016/j.exger.2011.08.005 [doi] PST - ppublish SO - Exp Gerontol. 2011 Nov;46(11):934-45. doi: 10.1016/j.exger.2011.08.005. Epub 2011 Aug 16.