PMID- 21872448
OWN - NLM
STAT- MEDLINE
DCOM- 20120104
LR  - 20110905
IS  - 1873-569X (Electronic)
IS  - 0923-1811 (Linking)
VI  - 64
IP  - 1
DP  - 2011 Oct
TI  - Erythrodermic cutaneous T-cell lymphoma: how to differentiate this rare disease 
      from atopic dermatitis.
PG  - 1-6
LID - 10.1016/j.jdermsci.2011.07.007 [doi]
AB  - Sezary syndrome and erythrodermic mycosis fungoides have been recognized as part 
      of a broader spectrum of erythrodermic cutaneous T-cell lymphoma (E-CTCL). Atopic 
      dermatitis (AD) is the most common, chronic inflammatory skin disease and can, in 
      its most severe form, manifest as erythroderma. It is often difficult to 
      clinically distinguish E-CTCL from various common and benign diseases presenting 
      as erythroderma, including AD. Differentiating E-CTCL from benign inflammatory 
      diseases is important to ensure proper disease management, and to provide 
      accurate prognostic information. Clinical and laboratory features, including 
      pruritus and serum levels of soluble interleukin-2 receptor, lactate 
      dehydrogenase (LDH), immunoglobulin E (IgE), and several chemokines, do not 
      differentiate E-CTCL from AD. In contrast, low serum allergen-specific IgE 
      levels, presence of Sezary cells in peripheral blood, histological findings, and 
      high CD4/CD8 ratio and CCR10 positivity in lesional skin are helpful in reaching 
      a correct diagnosis. Patients with E-CTCL have been treated with oral etretinate, 
      intravenous or subcutaneous interferon, bexarotene, extracorporeal photopheresis, 
      total body surface electron beam, chemotherapy, or any combination of these 
      modalities. Older patients, high serum LDH levels, and high number of circulating 
      atypical lymphocytes are associated with poor prognosis.
CI  - Copyright (c) 2011 Japanese Society for Investigative Dermatology. Published by 
      Elsevier Ireland Ltd. All rights reserved.
FAU - Miyagaki, Tomomitsu
AU  - Miyagaki T
AD  - Department of Dermatology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, 
      Bunkyo-ku, Tokyo 113-8655, Japan.
FAU - Sugaya, Makoto
AU  - Sugaya M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110805
PL  - Netherlands
TA  - J Dermatol Sci
JT  - Journal of dermatological science
JID - 9011485
RN  - 0 (CCR10 protein, human)
RN  - 0 (Receptors, CCR10)
RN  - 0 (Receptors, Interleukin-2)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - EC 1.1.1.27 (L-Lactate Dehydrogenase)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Dermatitis, Atopic/*diagnosis/pathology
MH  - Dermatology/methods
MH  - Diagnosis, Differential
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/metabolism
MH  - L-Lactate Dehydrogenase/metabolism
MH  - Lymphoma, T-Cell, Cutaneous/*diagnosis/pathology
MH  - Male
MH  - Medical Oncology/methods
MH  - Middle Aged
MH  - Mycosis Fungoides/metabolism
MH  - Prognosis
MH  - Pruritus/diagnosis/pathology
MH  - Receptors, CCR10/metabolism
MH  - Receptors, Interleukin-2/metabolism
MH  - Sezary Syndrome/diagnosis/metabolism
MH  - Treatment Outcome
EDAT- 2011/08/30 06:00
MHDA- 2012/01/05 06:00
CRDT- 2011/08/30 06:00
PHST- 2011/06/27 00:00 [received]
PHST- 2011/07/20 00:00 [revised]
PHST- 2011/07/28 00:00 [accepted]
PHST- 2011/08/30 06:00 [entrez]
PHST- 2011/08/30 06:00 [pubmed]
PHST- 2012/01/05 06:00 [medline]
AID - S0923-1811(11)00230-1 [pii]
AID - 10.1016/j.jdermsci.2011.07.007 [doi]
PST - ppublish
SO  - J Dermatol Sci. 2011 Oct;64(1):1-6. doi: 10.1016/j.jdermsci.2011.07.007. Epub 
      2011 Aug 5.