PMID- 21872663
OWN - NLM
STAT- MEDLINE
DCOM- 20120313
LR  - 20111118
IS  - 1095-9947 (Electronic)
IS  - 1050-4648 (Linking)
VI  - 31
IP  - 6
DP  - 2011 Dec
TI  - The first homolog of a TRAF7 (TNF receptor-associated factor 7) gene in a 
      mollusk, Crassostrea hongkongensis.
PG  - 1208-10
LID - 10.1016/j.fsi.2011.08.007 [doi]
AB  - Tumor necrosis factor (TNF) receptor-associated factor 7 (TRAF7) is one of 
      several adaptor proteins that are critically involved in the activation of 
      TLR-dependent NF-kappaB signaling. In this report, the first mollusk TRAF7 
      (designated ChTRAF7) homolog was isolated from Crassostrea hongkongensis by 
      screening a suppression subtractive library. The full-length cDNA, 2290 bp in 
      length, encodes a putative protein of 686 amino acids that contains a RING finger 
      domain, an adjacent zinc finger domain, and seven WD40 repeats. ChTRAF7 is 
      ubiquitously expressed in various tissues including digestive gland, mantle, 
      gill, heart, hemocytes, muscle, and gonads, with the highest expression observed 
      in gonads. Temporal expression of ChTRAF7 following bacterial infection shows 
      that expression of ChTRAF7 in hemocytes decreases from 2 to 12 h post-challenge, 
      and then recovered to the original level after 24 h. These results indicate that 
      ChTRAF7 may play an important role in signal transduction in the immune response 
      of oysters.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Fu, Dingkun
AU  - Fu D
AD  - Key Laboratory of Marine Bio-resource Sustainable Utilization, Laboratory of 
      Applied Marine Biology, South China Sea Institute of Oceanology, Chinese Academy 
      of Sciences, 164 West Xingang Road, Guangzhou 510301, China.
FAU - Zhang, Yang
AU  - Zhang Y
FAU - Xiao, Shu
AU  - Xiao S
FAU - Yu, Ziniu
AU  - Yu Z
LA  - eng
SI  - GENBANK/JN029960
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110823
PL  - England
TA  - Fish Shellfish Immunol
JT  - Fish & shellfish immunology
JID - 9505220
RN  - 0 (DNA Primers)
RN  - 0 (DNA, Complementary)
RN  - 0 (Tumor Necrosis Factor Receptor-Associated Peptides and Proteins)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - China
MH  - Computational Biology
MH  - Crassostrea/*genetics/microbiology
MH  - DNA Primers/genetics
MH  - DNA, Complementary/genetics
MH  - Gene Expression Profiling
MH  - Gene Expression Regulation/*immunology
MH  - Gene Library
MH  - Molecular Sequence Data
MH  - Real-Time Polymerase Chain Reaction
MH  - Sequence Analysis, DNA
MH  - Signal Transduction/*genetics/immunology
MH  - Tumor Necrosis Factor Receptor-Associated Peptides and Proteins/*genetics
MH  - Vibrio alginolyticus/*immunology
EDAT- 2011/08/30 06:00
MHDA- 2012/03/14 06:00
CRDT- 2011/08/30 06:00
PHST- 2011/06/04 00:00 [received]
PHST- 2011/08/12 00:00 [revised]
PHST- 2011/08/16 00:00 [accepted]
PHST- 2011/08/30 06:00 [entrez]
PHST- 2011/08/30 06:00 [pubmed]
PHST- 2012/03/14 06:00 [medline]
AID - S1050-4648(11)00312-3 [pii]
AID - 10.1016/j.fsi.2011.08.007 [doi]
PST - ppublish
SO  - Fish Shellfish Immunol. 2011 Dec;31(6):1208-10. doi: 10.1016/j.fsi.2011.08.007. 
      Epub 2011 Aug 23.