PMID- 21872672
OWN - NLM
STAT- MEDLINE
DCOM- 20120222
LR  - 20111010
IS  - 1095-9564 (Electronic)
IS  - 1074-7427 (Linking)
VI  - 96
IP  - 3
DP  - 2011 Oct
TI  - Voluntary exercise ameliorates cognitive deficits in morphine dependent rats: the 
      role of hippocampal brain-derived neurotrophic factor.
PG  - 479-91
LID - 10.1016/j.nlm.2011.08.001 [doi]
AB  - Chronic exposure to opiates impairs spatial learning and memory. Given the 
      well-known beneficial effects of voluntary exercise on cognitive functions, we 
      investigated whether voluntary exercise would ameliorate the cognitive deficits 
      that are induced by morphine dependence. If an effect of exercise was observed, 
      we aimed to investigate the possible role of hippocampal brain-derived 
      neurotrophic factor (BDNF) in the exercise-induced enhancement of learning and 
      memory in morphine-dependent rats. The rats were injected with bi-daily doses 
      (10mg/kg, at 12h intervals) of morphine over a period of 10 days of voluntary 
      exercise. Following these injections, a water maze task was performed twice a day 
      for five consecutive days, followed by a probe trial 2 days later. A specific 
      BDNF inhibitor (TrkB-IgG chimera) was used to block the hippocampal BDNF action 
      during the 10 days of voluntary exercise. We found that voluntary exercise 
      blocked the ability of chronic morphine to impair spatial memory retention. A 
      blockade of the BDNF action blunted the exercise-induced improvement of spatial 
      memory in the dependent rats. Moreover, the voluntary exercise diminished the 
      severity of the rats' dependency on morphine. This study demonstrates that 
      voluntary exercise ameliorates, via a TrkB-mediated mechanism, the cognitive 
      deficits that are induced by chronic morphine. Thus, voluntary exercise might be 
      a potential method to ameliorate some of the deleterious behavioral consequences 
      of the abuse of morphine and other opiates.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Miladi-Gorji, Hossein
AU  - Miladi-Gorji H
AD  - Dept. of Physiology, School of Medical Sciences, Tarbiat Modares University, 
      Tehran, Iran.
FAU - Rashidy-Pour, Ali
AU  - Rashidy-Pour A
FAU - Fathollahi, Yaghoub
AU  - Fathollahi Y
FAU - Akhavan, Maziar M
AU  - Akhavan MM
FAU - Semnanian, Saeed
AU  - Semnanian S
FAU - Safari, Manouchehr
AU  - Safari M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110822
PL  - United States
TA  - Neurobiol Learn Mem
JT  - Neurobiology of learning and memory
JID - 9508166
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*physiology
MH  - Cognition Disorders/*complications
MH  - Hippocampus/drug effects/metabolism
MH  - Male
MH  - Maze Learning/drug effects/*physiology
MH  - Morphine Dependence/*complications/physiopathology
MH  - Motor Activity/*physiology
MH  - Physical Conditioning, Animal/physiology
MH  - Rats
MH  - Rats, Wistar
MH  - Receptor, trkB/drug effects/physiology
MH  - Spatial Behavior/drug effects/physiology
MH  - Statistics, Nonparametric
EDAT- 2011/08/30 06:00
MHDA- 2012/02/23 06:00
CRDT- 2011/08/30 06:00
PHST- 2011/05/09 00:00 [received]
PHST- 2011/06/28 00:00 [revised]
PHST- 2011/08/08 00:00 [accepted]
PHST- 2011/08/30 06:00 [entrez]
PHST- 2011/08/30 06:00 [pubmed]
PHST- 2012/02/23 06:00 [medline]
AID - S1074-7427(11)00144-4 [pii]
AID - 10.1016/j.nlm.2011.08.001 [doi]
PST - ppublish
SO  - Neurobiol Learn Mem. 2011 Oct;96(3):479-91. doi: 10.1016/j.nlm.2011.08.001. Epub 
      2011 Aug 22.