PMID- 21872828
OWN - NLM
STAT- MEDLINE
DCOM- 20111021
LR  - 20110829
IS  - 2210-7762 (Print)
VI  - 204
IP  - 7
DP  - 2011 Jul
TI  - Absence of TCR loci chromosomal translocations in cutaneous T-cell lymphomas.
PG  - 405-9
LID - 10.1016/j.cancergen.2011.05.004 [doi]
AB  - Chromosomal aberrations involving T-cell receptor (TCR) gene loci have been 
      described in several T-cell malignancies. In primary cutaneous T-cell lymphomas 
      (CTCL), the frequency of these aberrations has not yet been well established. We 
      analyzed TCR gene loci (TCRAD, TCRB, and TCRG) status in CTCLs by fluorescence in 
      situ hybridization (FISH). Twenty-five patients with CTCLs were included in the 
      study: 13 Sezary syndromes (SS), six tumoral stage mycosis fungoides (MFt), and 
      six primary cutaneous anaplastic large cell lymphomas CD30(+) (cALCL-CD30(+)). 
      FISH was performed with three break-apart probes flanking TCRAD (14q11), TCRB 
      (7q34), and TCRG (7p14) loci in each case. TCR gene chromosomal rearrangements 
      were not detected in any of the analyzed cases. Gains of TCRB and TCRG genes were 
      observed in 23% (3 of 13) of SS and 50% (3 of 6) of MFt, reflecting the presence 
      of trisomy and/or tetrasomy of chromosome 7 already detected by conventional 
      cytogenetics and array comparative genetic hybridization techniques. TCR loci 
      rearrangements are not frequent in CTCLs; however, we cannot exclude a pathogenic 
      role in these malignancies.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Salgado, Rocio
AU  - Salgado R
AD  - Laboratori de Citogenetica Molecular, Laboratori de Citologia Hematologica, 
      Servei de Patologia, Hospital del Mar-Parc de Salut Mar, IMIM-Institut de Recerca 
      de l'Hospital del Mar, Programa de Recerca en Cancer, GRETNHE, Barcelona, Spain.
FAU - Gallardo, Fernando
AU  - Gallardo F
FAU - Servitje, Octavio
AU  - Servitje O
FAU - Estrach, Teresa
AU  - Estrach T
FAU - Garcia-Muret, Maria Pilar
AU  - Garcia-Muret MP
FAU - Romagosa, Vicente
AU  - Romagosa V
FAU - Florensa, Lourdes
AU  - Florensa L
FAU - Serrano, Sergi
AU  - Serrano S
FAU - Salido, Marta
AU  - Salido M
FAU - Sole, Francesc
AU  - Sole F
FAU - Pujol, Ramon M
AU  - Pujol RM
FAU - Espinet, Blanca
AU  - Espinet B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet
JT  - Cancer genetics
JID - 101539150
RN  - 0 (Receptors, Antigen, T-Cell)
RN  - 0 (Receptors, Antigen, T-Cell, alpha-beta)
RN  - 0 (Receptors, Antigen, T-Cell, gamma-delta)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Chromosomes, Human, Pair 7/genetics
MH  - Female
MH  - *Genes, T-Cell Receptor
MH  - Genetic Loci
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - Mycosis Fungoides/*genetics/metabolism
MH  - Receptors, Antigen, T-Cell/genetics/metabolism
MH  - Receptors, Antigen, T-Cell, alpha-beta/genetics
MH  - Receptors, Antigen, T-Cell, gamma-delta/genetics
MH  - Retrospective Studies
MH  - Sezary Syndrome/*genetics/pathology
MH  - Skin Neoplasms/*genetics/pathology
MH  - *Tetrasomy
MH  - *Translocation, Genetic
EDAT- 2011/08/30 06:00
MHDA- 2011/10/22 06:00
CRDT- 2011/08/30 06:00
PHST- 2011/03/04 00:00 [received]
PHST- 2011/05/05 00:00 [revised]
PHST- 2011/05/11 00:00 [accepted]
PHST- 2011/08/30 06:00 [entrez]
PHST- 2011/08/30 06:00 [pubmed]
PHST- 2011/10/22 06:00 [medline]
AID - S2210-7762(11)00121-9 [pii]
AID - 10.1016/j.cancergen.2011.05.004 [doi]
PST - ppublish
SO  - Cancer Genet. 2011 Jul;204(7):405-9. doi: 10.1016/j.cancergen.2011.05.004.