PMID- 21874610
OWN - NLM
STAT- MEDLINE
DCOM- 20120917
LR  - 20211020
IS  - 1867-0687 (Electronic)
VI  - 8
IP  - 2
DP  - 2012 May
TI  - Sweet's syndrome in a neonate with non-B54 types of human leukocyte antigen.
PG  - 181-4
LID - 10.1007/s12519-011-0308-2 [doi]
AB  - BACKGROUND: Sweet's syndrome (acute febrile neutrophilic dermatosis) is 
      characterized by fever, polymorphonuclear leukocytosis of blood, painful plaques 
      on the limbs, face and neck, and histologically a dense dermal infiltration with 
      mature neutrophils. Sweet's syndrome is often a complication of hematologic 
      malignant disease or drug-induced sensitivity reactions and has a significant 
      susceptibility correlated with certain human leukocyte antigen (HLA). METHODS: A 
      5-week-old Japanese girl with Sweet's syndrome confirmed by skin biopsy was 
      successfully treated and HLA analysis was performed. RESULTS: The patient was one 
      of the youngest patients reported with Sweet's syndrome, suggesting the 
      importance of the genetic background. Although the HLA types of the patient did 
      not have B54, which was reported as a significant susceptibility correlation, 
      structural analysis of the patient's HLAs suggested a similar possible motif for 
      the bound peptides. CONCLUSION: Studies on the HLA bound peptides and HLA 
      structural analysis for patients with Sweet's syndrome would be valuable for 
      understanding the molecular mechanism of the pathogenesis.
FAU - Omoya, Kentaro
AU  - Omoya K
AD  - Department of Pediatrics, Nagahama City Hospital, Nagahama, Shiga, Japan.
FAU - Naiki, Yasuhiro
AU  - Naiki Y
FAU - Kato, Zenichiro
AU  - Kato Z
FAU - Yoshioka, Seiichiro
AU  - Yoshioka S
FAU - Uchida, Yasushi
AU  - Uchida Y
FAU - Taga, Toshiaki
AU  - Taga T
FAU - Aoki, Yoshinori
AU  - Aoki Y
FAU - Deguchi, Hideki
AU  - Deguchi H
FAU - Kondo, Naomi
AU  - Kondo N
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20110827
PL  - Switzerland
TA  - World J Pediatr
JT  - World journal of pediatrics : WJP
JID - 101278599
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Female
MH  - HLA Antigens/classification/*immunology
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Sweet Syndrome/*diagnosis/*immunology
EDAT- 2011/08/30 06:00
MHDA- 2012/09/18 06:00
CRDT- 2011/08/30 06:00
PHST- 2009/11/19 00:00 [received]
PHST- 2010/02/09 00:00 [accepted]
PHST- 2011/08/30 06:00 [entrez]
PHST- 2011/08/30 06:00 [pubmed]
PHST- 2012/09/18 06:00 [medline]
AID - 10.1007/s12519-011-0308-2 [doi]
PST - ppublish
SO  - World J Pediatr. 2012 May;8(2):181-4. doi: 10.1007/s12519-011-0308-2. Epub 2011 
      Aug 27.