PMID- 21875455
OWN - NLM
STAT- MEDLINE
DCOM- 20121228
LR  - 20220318
IS  - 1469-5111 (Electronic)
IS  - 1461-1457 (Linking)
VI  - 15
IP  - 8
DP  - 2012 Sep
TI  - The brain-derived neurotrophic factor gene in suicidal behaviour: a 
      meta-analysis.
PG  - 1037-42
LID - 10.1017/S1461145711001313 [doi]
AB  - Suicide is a prominent public health problem. Its aetiology is complex, and the 
      brain-derived neurotrophic factor (BDNF) has been implicated. We performed the 
      first meta-analysis of the functional BDNF marker Val(6)(6)Met (rs6265, 196G>A) in 
      suicidal behaviour using data from 11 previously published samples plus our 
      present sample (total n=3352 subjects, 1202 with history of suicidal behaviour. 
      The meta-analysis including all 12 studies showed a trend for the Met-carrying 
      genotypes and Met allele conferring risk for suicide (random-effects model 
      p=0.096; ORMet-carrier=1.13, 95% CI 0.98-1.30, and random-effects model p=0.032; 
      ORMet=1.16, 95% CI 1.01-1.32, respectively). Furthermore, we found the Met allele 
      and the Met allele-carrying genotypes to be associated with history of suicide 
      attempt (eight studies; allelic meta-analysis--random-effects model: p=0.013; 
      fixed-effects model: p=0.006; genotypic meta-analysis--random-effects model: 
      p=0.017; fixed-effects model: p=0.008). Taken together, the results from our 
      study suggest that BDNF Val(6)(6)Met is involved in suicidality. Further studies are 
      required to elucidate its role in suicidal behaviour.
FAU - Zai, Clement C
AU  - Zai CC
AD  - Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, ON, 
      Canada. clement_zai@camh.net
FAU - Manchia, Mirko
AU  - Manchia M
FAU - De Luca, Vincenzo
AU  - De Luca V
FAU - Tiwari, Arun K
AU  - Tiwari AK
FAU - Chowdhury, Nabilah I
AU  - Chowdhury NI
FAU - Zai, Gwyneth C
AU  - Zai GC
FAU - Tong, Ryan P
AU  - Tong RP
FAU - Yilmaz, Zeynep
AU  - Yilmaz Z
FAU - Shaikh, Sajid A
AU  - Shaikh SA
FAU - Strauss, John
AU  - Strauss J
FAU - Kennedy, James L
AU  - Kennedy JL
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20110830
PL  - England
TA  - Int J Neuropsychopharmacol
JT  - The international journal of neuropsychopharmacology
JID - 9815893
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Gene Frequency
MH  - Genotype
MH  - Humans
MH  - Methionine/genetics
MH  - Odds Ratio
MH  - *Suicide
MH  - Valine/genetics
EDAT- 2011/08/31 06:00
MHDA- 2012/12/29 06:00
CRDT- 2011/08/31 06:00
PHST- 2011/08/31 06:00 [entrez]
PHST- 2011/08/31 06:00 [pubmed]
PHST- 2012/12/29 06:00 [medline]
AID - S1461145711001313 [pii]
AID - 10.1017/S1461145711001313 [doi]
PST - ppublish
SO  - Int J Neuropsychopharmacol. 2012 Sep;15(8):1037-42. doi: 
      10.1017/S1461145711001313. Epub 2011 Aug 30.