PMID- 21875661
OWN - NLM
STAT- MEDLINE
DCOM- 20120503
LR  - 20131121
IS  - 1872-7573 (Electronic)
IS  - 0378-8741 (Linking)
VI  - 138
IP  - 1
DP  - 2011 Oct 31
TI  - Cortex Mori Radicis extract exerts antiasthmatic effects via enhancement of 
      CD4(+)CD25(+)Foxp3(+) regulatory T cells and inhibition of Th2 cytokines in a 
      mouse asthma model.
PG  - 40-6
LID - 10.1016/j.jep.2011.08.021 [doi]
AB  - ETHONOPHARMACOLOGICAL RELEVANCE: Cortex Mori Radicis (CMR), the root epidermis of 
      Morus alba L., has been traditionally used for cough treatment in Oriental 
      medicine. In the present study, immunological mechanism of CMR in inhibition of 
      airway hyperresponsiveness (AHR) was investigated in a mouse asthma model. 
      MATERIALS AND METHODS: Experimental asthma model was established in Balb/c mice 
      sensitized by ovalbumin (OVA), followed by aerosol allergen challenges. CMR (50 
      or 200mg/kg) was orally administered for 6-weeks from 3-weeks after OVA 
      sensitization. AHR, pulmonary eosinophilic accumulation, immunoglobulin E (IgE), 
      histamine, Th2 cytokine expression, and CD4(+)CD25(+)Foxp3(+) regulatory T cells 
      (Tregs) were evaluated by flow cytometry, enzyme-linked immunosorbent assay 
      (ELISA) and reverse transcription-polymerase chain reaction (RT-PCR). RESULTS: 
      CMR significantly reduced AHR response, eosinophil infiltration, and production 
      of serum histamine and OVA-specific IgE. Furthermore, CMR suppressed Th2 
      cytokines such as interleukin (IL)-4, -5 and -13 at protein (secreted) and mRNA 
      levels. Of note, CMR significantly increased Foxp3(+) Tregs population and 
      enhanced Foxp3(+) mRNA expression in a mouse asthma model. CONCLUSIONS: CMR 
      exerts anti-allergic effect via enhancement of CD4(+)CD25(+)Foxp3(+) regulatory T 
      cells and inhibition of Th2 cytokines in a mouse asthma model as a potent 
      anti-asthmatic agent.
CI  - Copyright A(c) 2011 Elsevier Ireland Ltd. All rights reserved.
FAU - Kim, Hyun-Ji
AU  - Kim HJ
AD  - The Department of Oriental Pediatrics, College of Oriental Medicine, Wonkwang 
      University, Iksan 570-749, South Korea.
FAU - Lee, Hai Ja
AU  - Lee HJ
FAU - Jeong, Soo-Jin
AU  - Jeong SJ
FAU - Lee, Hyo-Jeong
AU  - Lee HJ
FAU - Kim, Sung-Hoon
AU  - Kim SH
FAU - Park, Eun-Jung
AU  - Park EJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110822
PL  - Ireland
TA  - J Ethnopharmacol
JT  - Journal of ethnopharmacology
JID - 7903310
RN  - 0 (Allergens)
RN  - 0 (Anti-Asthmatic Agents)
RN  - 0 (Cytokines)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Forkhead Transcription Factors)
RN  - 0 (Foxp3 protein, mouse)
RN  - 0 (RNA, Messenger)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 820484N8I3 (Histamine)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Allergens/administration & dosage
MH  - Animals
MH  - Anti-Asthmatic Agents/*pharmacology/therapeutic use
MH  - Asthma/drug therapy/*immunology
MH  - Cytokines/*metabolism
MH  - Disease Models, Animal
MH  - Drugs, Chinese Herbal/*pharmacology/therapeutic use
MH  - Eosinophils/metabolism
MH  - Female
MH  - Forkhead Transcription Factors/genetics/*metabolism
MH  - Histamine/blood
MH  - Immunoglobulin E/blood
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - *Morus
MH  - Ovalbumin
MH  - Phytotherapy
MH  - Plant Bark
MH  - Plant Roots
MH  - RNA, Messenger/metabolism
MH  - Respiratory System/drug effects/metabolism
MH  - T-Lymphocytes, Regulatory/*metabolism
MH  - Th2 Cells/metabolism
EDAT- 2011/08/31 06:00
MHDA- 2012/05/04 06:00
CRDT- 2011/08/31 06:00
PHST- 2011/05/06 00:00 [received]
PHST- 2011/07/11 00:00 [revised]
PHST- 2011/08/11 00:00 [accepted]
PHST- 2011/08/31 06:00 [entrez]
PHST- 2011/08/31 06:00 [pubmed]
PHST- 2012/05/04 06:00 [medline]
AID - S0378-8741(11)00594-0 [pii]
AID - 10.1016/j.jep.2011.08.021 [doi]
PST - ppublish
SO  - J Ethnopharmacol. 2011 Oct 31;138(1):40-6. doi: 10.1016/j.jep.2011.08.021. Epub 
      2011 Aug 22.