PMID- 2187708
OWN - NLM
STAT- MEDLINE
DCOM- 19900627
LR  - 20220419
IS  - 0903-1936 (Print)
IS  - 0903-1936 (Linking)
VI  - 3
IP  - 3
DP  - 1990 Mar
TI  - The role of increased airway microvascular permeability and plasma exudation in 
      asthma.
PG  - 329-37
AB  - Airway oedema and inflammation are recognized as cardinal features of asthma, 
      resulting from increase microvascular permeability of the bronchial circulation 
      with the exudation of plasma and inflammatory cells into the airway lumen. 
      Resistance to airflow is increased and the epithelium is disrupted either 
      directly or by cytotoxic proteins derived from migrating inflammatory cells. Such 
      mediators include bradykinin, platelet-activating factor (PAF), leukotrienes and 
      histamine. Antigen-induced and neurogenic inflammation, generated by 
      immunoglobulin E (IgE) and neuropeptides respectively, may also contribute to 
      oedema generation. Assessment of increased bronchial vascular permeability in 
      animals has largely involved measurement of the extravasation of radiolabelled 
      albumin or protein-bound dyes. Non-invasive techniques are less reliable in 
      humans, but measurement of the rate of clearance of inhaled particles labelled 
      with isotope may prove successful. Airway oedema appears to be an important 
      feature of asthma and future research may be aimed at developing drugs that 
      specifically prevent airway microvascular leakage.
FAU - Chung, K F
AU  - Chung KF
AD  - Dept of Thoracic Medicine, National Heart and Lung Institute, London, UK.
FAU - Rogers, D F
AU  - Rogers DF
FAU - Barnes, P J
AU  - Barnes PJ
FAU - Evans, T W
AU  - Evans TW
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Eur Respir J
JT  - The European respiratory journal
JID - 8803460
SB  - IM
MH  - Animals
MH  - Asthma/drug therapy/pathology/*physiopathology
MH  - Capillary Permeability/*physiology
MH  - Edema/etiology
MH  - Epithelium/pathology/physiology
MH  - Extravasation of Diagnostic and Therapeutic Materials/physiopathology
MH  - Humans
MH  - Inflammation/etiology
RF  - 105
EDAT- 1990/03/01 00:00
MHDA- 1990/03/01 00:01
CRDT- 1990/03/01 00:00
PHST- 1990/03/01 00:00 [pubmed]
PHST- 1990/03/01 00:01 [medline]
PHST- 1990/03/01 00:00 [entrez]
PST - ppublish
SO  - Eur Respir J. 1990 Mar;3(3):329-37.