PMID- 21878071
OWN - NLM
STAT- MEDLINE
DCOM- 20111018
LR  - 20170310
IS  - 0022-9040 (Print)
IS  - 0022-9040 (Linking)
VI  - 51
IP  - 6
DP  - 2011
TI  - [Eosinophilic cation protein and development of restenosis of drug covered 
      stents].
PG  - 49-54
AB  - Aim of the study was to assess activation of eosinophils as well as allergic and 
      inflammatory reactions of the body in development of restenosis after 
      implantation of stents with drug covering. We included into the study 32 patients 
      with ischemic heart disease (IHD) and stable angina subjected to repeat coronary 
      angiography during first year after endovascular myocardial revascularization 
      with the help of stents with drug covering, and 11 healthy persons. Levels of 
      eosinophilic cation protein (ECP), immunoglobulin E (IgE), and C-reactive protein 
      (CRP) in blood plasma of patients and healthy persons was determined by 
      immunoenzyme assay. According to results of angiographic study patients were 
      divided into 2 groups: the first comprised 19 patients in whom no instent 
      restenosis was found, the second comprised 13 patients in whom formation of 
      restenosis at least in one stent was noted. Patients in these groups did not 
      differ by age, sex, smokers and nonsmokers ratio, presence of hyperlipidemia, and 
      angiographical characteristics of involved arteries. In patients with restenosis 
      of stents blood plasma ECP level was 17.7 (11.2-24.0) g/ml and significantly 
      higher than in patients without restenosis [9.0 (6.4-12.9) g/ml; p=0.017]. Blood 
      level of IgE in these groups of patients did not differ [58.8 (42.1-164.0) and 
      52.9 (12.8-76.1) mg/ml, respectively; p=0.40] and did not differ from IgE level 
      in blood of healthy volunteers [32.0 (21.2-80.8) mg/ml; p=0.91]. CRP level in 
      patients with IHD was higher than in healthy volunteers [0.36 (0.1-0.75) mg/ml; 
      p=0.0008)], but did not differ significantly in groups of patients with and 
      without restenosis [2.38 (0.30-4.08) and 1.63 (0.61-2.47) mg/ml, respectively; 
      p=0.52]. It was found that in the group of patients with low blood level of ECP 
      (<11 g/ml) restenoses were revealed in 19% while in the group with higher 
      blood level of ECP (>11 g/ml) - in 62% of cases (p=0,019). In patients 
      subjected to coronary stenting with higher level of ECP in blood we noted more 
      frequent development of restenoses than in patients with low level of this 
      protein. The data obtained allow to suggest presence of relationship between 
      development of restenosis and elevated activity of eosinophilic granulocytes in 
      patients with IHD after revascularization.
FAU - Gabbasov, Z A
AU  - Gabbasov ZA
FAU - Kozlov, S G
AU  - Kozlov SG
FAU - Saburova, O S
AU  - Saburova OS
FAU - Imaeva, A E
AU  - Imaeva AE
FAU - Bosykh, E G
AU  - Bosykh EG
FAU - Liakishev, A A
AU  - Liakishev AA
FAU - Zykov, K A
AU  - Zykov KA
FAU - Masenko, V P
AU  - Masenko VP
LA  - rus
PT  - English Abstract
PT  - Journal Article
PL  - Russia (Federation)
TA  - Kardiologiia
JT  - Kardiologiia
JID - 0376351
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - EC 3.1.27.- (Eosinophil Cationic Protein)
SB  - IM
MH  - Angina Pectoris/diagnosis/*metabolism/pathology/therapy
MH  - Angioplasty, Balloon, Coronary/adverse effects
MH  - C-Reactive Protein/analysis
MH  - Coronary Angiography
MH  - Coronary Restenosis/etiology/*metabolism
MH  - Coronary Vessels/metabolism/pathology
MH  - Drug-Eluting Stents/*adverse effects
MH  - Eosinophil Cationic Protein/*blood
MH  - Eosinophils/*metabolism
MH  - Female
MH  - Humans
MH  - Hypersensitivity/etiology/metabolism
MH  - Immunoenzyme Techniques
MH  - Immunoglobulin E/blood
MH  - Inflammation/etiology/metabolism
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
EDAT- 2011/09/01 06:00
MHDA- 2011/10/19 06:00
CRDT- 2011/09/01 06:00
PHST- 2011/09/01 06:00 [entrez]
PHST- 2011/09/01 06:00 [pubmed]
PHST- 2011/10/19 06:00 [medline]
PST - ppublish
SO  - Kardiologiia. 2011;51(6):49-54.