PMID- 21878528
OWN - NLM
STAT- MEDLINE
DCOM- 20111223
LR  - 20220317
IS  - 1549-5485 (Electronic)
IS  - 1072-0502 (Print)
IS  - 1072-0502 (Linking)
VI  - 18
IP  - 9
DP  - 2011
TI  - Running is the neurogenic and neurotrophic stimulus in environmental enrichment.
PG  - 605-9
LID - 10.1101/lm.2283011 [doi]
AB  - Environmental enrichment (EE) increases dentate gyrus (DG) neurogenesis and 
      brain-derived neurotrophic factor (BDNF) levels. However, running is considered 
      an element of EE. To dissociate effects of physical activity and enrichment on 
      hippocampal neurogenesis and BDNF levels, young female C57Bl/6 mice were housed 
      under control, running, enrichment, or enrichment plus running conditions, and 
      injected with bromodeoxyuridine. Cell genesis was assessed after 12 d and 
      differentiation was analyzed 1 mo later. In addition, locomotor activity in the 
      open field and hippocampal mature BDNF peptide levels were measured. Open-field 
      adaptation was improved in all groups, compared to controls, but more so with 
      running. New cell proliferation, survival, neuron number, and neurotrophin levels 
      were enhanced only when running was accessible. We conclude that exercise is the 
      critical factor mediating increased BDNF levels and adult hippocampal 
      neurogenesis.
FAU - Kobilo, Tali
AU  - Kobilo T
AD  - Neuroplasticity and Behavior Unit, Laboratory of Neurosciences, Intramural 
      Research Program, National Institute on Aging, Baltimore, Maryland 21224, USA.
FAU - Liu, Qing-Rong
AU  - Liu QR
FAU - Gandhi, Kriti
AU  - Gandhi K
FAU - Mughal, Mohammed
AU  - Mughal M
FAU - Shaham, Yavin
AU  - Shaham Y
FAU - van Praag, Henriette
AU  - van Praag H
LA  - eng
GR  - Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
DEP - 20110830
PL  - United States
TA  - Learn Mem
JT  - Learning & memory (Cold Spring Harbor, N.Y.)
JID - 9435678
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - G34N38R2N1 (Bromodeoxyuridine)
SB  - IM
MH  - Animals
MH  - Behavior, Animal
MH  - Brain-Derived Neurotrophic Factor/*pharmacology
MH  - Bromodeoxyuridine/metabolism
MH  - Cell Proliferation/drug effects
MH  - Cell Survival/drug effects
MH  - Dentate Gyrus/cytology/drug effects
MH  - *Environment
MH  - Exploratory Behavior/drug effects
MH  - Female
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Nerve Growth Factors/metabolism
MH  - Neurogenesis/*drug effects/physiology
MH  - Neurons/*drug effects/physiology
MH  - Running/*physiology
PMC - PMC3166785
EDAT- 2011/09/01 06:00
MHDA- 2011/12/24 06:00
PMCR- 2012/09/01
CRDT- 2011/09/01 06:00
PHST- 2011/09/01 06:00 [entrez]
PHST- 2011/09/01 06:00 [pubmed]
PHST- 2011/12/24 06:00 [medline]
PHST- 2012/09/01 00:00 [pmc-release]
AID - 18/9/605 [pii]
AID - KobiloLM22830 [pii]
AID - 10.1101/lm.2283011 [doi]
PST - epublish
SO  - Learn Mem. 2011 Aug 30;18(9):605-9. doi: 10.1101/lm.2283011. Print 2011.