PMID- 21879987
OWN - NLM
STAT- MEDLINE
DCOM- 20120112
LR  - 20131121
IS  - 1943-5681 (Electronic)
IS  - 0002-9645 (Linking)
VI  - 72
IP  - 9
DP  - 2011 Sep
TI  - Effects of hyperbaric oxygen treatment on horses with experimentally induced 
      endotoxemia.
PG  - 1266-75
LID - 10.2460/ajvr.72.9.1266 [doi]
AB  - OBJECTIVE: To determine the effectiveness of preinduction hyperbaric oxygen 
      treatment (HBOT) in ameliorating signs of experimentally induced endotoxemia in 
      horses. ANIMALS: 18 healthy adult horses. PROCEDURES: Horses were randomly 
      assigned to 1 of 3 equal-sized treatment groups to receive normobaric ambient air 
      and lipopolysaccharide (LPS), HBOT and LPS, or HBOT and physiologic saline (0.9% 
      NaCl) solution. Horses were physically examined, and blood was obtained for a CBC 
      and to determine concentration or activity of plasma tissue necrosis factor-alpha, 
      blood lactate, and blood glucose before the horses were treated with HBOT and 
      then intermittently for 6 hours after administration of LPS or physiologic saline 
      solution. RESULTS: All LPS-treated horses developed signs and biochemical and 
      hematologic changes consistent with endotoxemia. Treatment with HBOT 
      significantly ameliorated the effect of LPS on clinical endotoxemia score but did 
      not significantly improve other abnormalities associated with endotoxemia. 
      CONCLUSIONS AND CLINICAL RELEVANCE: The protective effect of HBOT was minimal, 
      and results did not support its use as a treatment for horses prior to 
      development of endotoxemia.
FAU - Baumwart, Chad A
AU  - Baumwart CA
AD  - Department of Large Animal Clinical Sciences, University of Tennessee, Knoxville, 
      TN 37996, USA.
FAU - Doherty, Tom J
AU  - Doherty TJ
FAU - Schumacher, James
AU  - Schumacher J
FAU - Willis, Rebekah S
AU  - Willis RS
FAU - Adair, Henry S 3rd
AU  - Adair HS 3rd
FAU - Rohrbach, Barton W
AU  - Rohrbach BW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Vet Res
JT  - American journal of veterinary research
JID - 0375011
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Animals
MH  - Blood Chemical Analysis/veterinary
MH  - Body Temperature
MH  - Endotoxemia/therapy/*veterinary
MH  - Female
MH  - Heart Rate
MH  - Horse Diseases/*therapy
MH  - Horses
MH  - Hyperbaric Oxygenation/*veterinary
MH  - Least-Squares Analysis
MH  - Lipopolysaccharides/administration & dosage/*adverse effects/pharmacology
MH  - Oxygen/blood/*therapeutic use
MH  - Respiratory Rate
MH  - Tumor Necrosis Factor-alpha/blood
EDAT- 2011/09/02 06:00
MHDA- 2012/01/13 06:00
CRDT- 2011/09/02 06:00
PHST- 2011/09/02 06:00 [entrez]
PHST- 2011/09/02 06:00 [pubmed]
PHST- 2012/01/13 06:00 [medline]
AID - 10.2460/ajvr.72.9.1266 [doi]
PST - ppublish
SO  - Am J Vet Res. 2011 Sep;72(9):1266-75. doi: 10.2460/ajvr.72.9.1266.