PMID- 21880305
OWN - NLM
STAT- MEDLINE
DCOM- 20120124
LR  - 20220409
IS  - 1872-6240 (Electronic)
IS  - 0006-8993 (Linking)
VI  - 1415
DP  - 2011 Sep 30
TI  - The brain-derived neurotrophic factor is associated with alcohol 
      dependence-related depression and antidepressant response.
PG  - 119-26
LID - 10.1016/j.brainres.2011.08.005 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) plays an essential role in neuronal 
      survival, proliferation, and synaptic remodeling and modulates the function of 
      many other neurotransmitters. Additionally, it likely underlies neurodegenerative 
      and psychiatric disorders, including alcohol dependence-related depression 
      (AD-D). Here, we investigated the possible association between three single 
      nucleotide polymorphisms (SNPs) of the BDNF gene (rs13306221, rs6265, rs16917204) 
      and AD-D. Of 548 patients with alcohol dependence (AD), 166 had AD-D and 312 
      healthy controls. Response to 8-week sertraline treatment was also assessed. The 
      frequency of the A allele of rs6265 (Val66Met) was significantly higher in AD-D 
      patients than in the healthy controls (p=0.009 after Bonferroni correction). The 
      analysis revealed a strong association between the rs6265 genotype distribution 
      and AD-D (p=0.005 after Bonferroni correction), and the A allele of rs6265 was 
      significantly overrepresented in AD-D patients compared to AD without depression 
      (AD-nD) patients (p=0.001 after Bonferroni correction). Additionally, carriers of 
      the A allele of rs6265 responded better to sertraline treatment (p=0.001). Our 
      results suggested a novel association between BDNF rs6265 and AD-D. These 
      findings might lead to earlier detection of AD-D, perhaps providing better tools 
      for clinical care of these patients in the future.
CI  - Copyright (c) 2011 Elsevier B.V. All rights reserved.
FAU - Su, N
AU  - Su N
AD  - Department of Neurosurgery, Xi Jing Hospital, Fourth Military Medical University, 
      Xi'an, Shannxi, PR China. suningxju@126.com
FAU - Zhang, L
AU  - Zhang L
FAU - Fei, F
AU  - Fei F
FAU - Hu, H
AU  - Hu H
FAU - Wang, K
AU  - Wang K
FAU - Hui, H
AU  - Hui H
FAU - Jiang, X F
AU  - Jiang XF
FAU - Li, X
AU  - Li X
FAU - Zhen, H N
AU  - Zhen HN
FAU - Li, J
AU  - Li J
FAU - Cao, B P
AU  - Cao BP
FAU - Dang, W
AU  - Dang W
FAU - Qu, Y
AU  - Qu Y
FAU - Zhou, F
AU  - Zhou F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110809
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - QUC7NX6WMB (Sertraline)
SB  - IM
MH  - Adult
MH  - Alcoholism/complications/genetics
MH  - Antidepressive Agents/*therapeutic use
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Chi-Square Distribution
MH  - China
MH  - Depression/*drug therapy/etiology/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Retrospective Studies
MH  - Sertraline/*therapeutic use
MH  - Surveys and Questionnaires
EDAT- 2011/09/02 06:00
MHDA- 2012/01/25 06:00
CRDT- 2011/09/02 06:00
PHST- 2011/05/11 00:00 [received]
PHST- 2011/07/14 00:00 [revised]
PHST- 2011/08/03 00:00 [accepted]
PHST- 2011/09/02 06:00 [entrez]
PHST- 2011/09/02 06:00 [pubmed]
PHST- 2012/01/25 06:00 [medline]
AID - S0006-8993(11)01441-7 [pii]
AID - 10.1016/j.brainres.2011.08.005 [doi]
PST - ppublish
SO  - Brain Res. 2011 Sep 30;1415:119-26. doi: 10.1016/j.brainres.2011.08.005. Epub 
      2011 Aug 9.