PMID- 21880655
OWN - NLM
STAT- MEDLINE
DCOM- 20120127
LR  - 20111021
IS  - 1468-201X (Electronic)
IS  - 1355-6037 (Linking)
VI  - 97
IP  - 22
DP  - 2011 Nov
TI  - Detection of very early stent healing after primary angioplasty: an optical 
      coherence tomographic observational study of chromium cobaltum and 
      first-generation drug-eluting stents. The DETECTIVE study.
PG  - 1841-6
LID - 10.1136/heartjnl-2011-300782 [doi]
AB  - BACKGROUND: Lack of stent coverage appears to be associated with stent 
      thrombosis, a problem of particular concern in patients with ST elevation 
      myocardial infarction (STEMI). METHODS: The DETECTIVE European Multicenter 
      Registry was set up to address the early modality of stent healing in the setting 
      of STEMI. The Registry compared, with an early optical coherence tomography (OCT) 
      evaluation performed at 3-7 days, the patterns of coverage and apposition of the 
      first generation of drug-eluting stents (DESs) and cobalt chromium 
      non-drug-eluting stents (CCSs) that were deployed in culprit lesions and in 
      non-culprit segments. The Registry included only patients with a multi-vessel 
      disease to allow, at 3-7 days from the first angioplasty, a deferred OCT 
      examination and a staged intervention in another vessel. RESULTS: 28 stented 
      lesions (15 patients) eventually entered the final OCT assessment. 13 stents were 
      first-generation DESs, while the remaining 15 were CCSs. 18 stents (64%) were 
      deployed at culprit STEMI lesions, and the remaining 10 (36%) were deployed at 
      non-culprit sites. The distribution of clinical and procedural variables in DES 
      and CCS as well as in culprit and non-culprit sites was not different. In total, 
      27,019 struts were analysed in 28 stents. The percentage of stent uncoverage in 
      the overall analysis was 11.7%, while the percentage of malapposition and that of 
      struts covered with thrombus were 4.8% and 2.2%, respectively. A low percentage 
      of strut uncoverage was found in all the four studied subgroups: DES 12.8%, CCS 
      10.9%, stents deployed in culprit lesions 13.2% and stents deployed in 
      non-culprit lesions 8.7%. CONCLUSIONS: In conclusion, our data show that in 
      patients with STEMI, a very high percentage of stent struts is covered by an 
      early thin rim of tissue within 7 days after stent positioning. The present data 
      bring new insights in the mechanism and timing of strut coverage.
FAU - Prati, Francesco
AU  - Prati F
AD  - Interventional Cardiology, San Giovanni Hospital, Rome, Italy. 
      fprati@hsangiovanni.roma.it
FAU - Stazi, Filippo
AU  - Stazi F
FAU - Dutary, Jaime
AU  - Dutary J
FAU - La Manna, Alessio
AU  - La Manna A
FAU - Di Giorgio, Alessandro
AU  - Di Giorgio A
FAU - Pawlosky, Tomasz
AU  - Pawlosky T
FAU - Gonzalo, Nieves
AU  - Gonzalo N
FAU - Di Salvo, Maria Elena
AU  - Di Salvo ME
FAU - Imola, Fabrizio
AU  - Imola F
FAU - Tamburino, Corrado
AU  - Tamburino C
FAU - Albertucci, Mario
AU  - Albertucci M
FAU - Alfonso, Fernando
AU  - Alfonso F
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
DEP - 20110831
PL  - England
TA  - Heart
JT  - Heart (British Cardiac Society)
JID - 9602087
RN  - 0 (Chromium Alloys)
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Angioplasty, Balloon, Coronary
MH  - Chromium Alloys/*therapeutic use
MH  - Coronary Restenosis/*prevention & control
MH  - *Drug-Eluting Stents
MH  - European Union
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/diagnosis/physiopathology/*therapy
MH  - Prospective Studies
MH  - Registries
MH  - Risk Factors
MH  - *Tomography, Optical Coherence
MH  - Treatment Outcome
MH  - Wound Healing
EDAT- 2011/09/02 06:00
MHDA- 2012/01/28 06:00
CRDT- 2011/09/02 06:00
PHST- 2011/09/02 06:00 [entrez]
PHST- 2011/09/02 06:00 [pubmed]
PHST- 2012/01/28 06:00 [medline]
AID - heartjnl-2011-300782 [pii]
AID - 10.1136/heartjnl-2011-300782 [doi]
PST - ppublish
SO  - Heart. 2011 Nov;97(22):1841-6. doi: 10.1136/heartjnl-2011-300782. Epub 2011 Aug 
      31.